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首页> 外文期刊>Journal of Clinical Medicine Research >Assessment of Interleukins IL-4, IL-6, IL-8, IL-10 in Acute Urticaria
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Assessment of Interleukins IL-4, IL-6, IL-8, IL-10 in Acute Urticaria

机译：急性荨麻疹中白介素IL-4，IL-6，IL-8，IL-10的评估

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Background: Urticaria is a skin disease that affects approximately 5% of the general population and manifests itself, not only as an acute but also as a chronic disease. The etiology of the disease varies as well as its clinical manifestations which extend from the presence of urticarial hives to the potentially mortal angioedema. There is a great interest to the disease not only due to its special clinical manifestation but also due to its pathogenetic mechanism. New data in the medical bibliography support the participation of interleukins (ILs) in the pathophysiology of urticaria. The aim of the study is to contribute in the comprehension of possible participation of certain ILs in the pathogenesis of acute urticaria. Methods: Our study concerns four ILs, IL-4, IL-6, IL-8 and IL-10, simultaneously and their quantitative changes during the acute phase of urticaria as well as 2 weeks after drug administration. Moreover, ILs levels of patients were compared with those of matched healthy controls. All measurements have been done by the ELISA method. The statistical analysis was done by SPSS. Results: The results present increased levels (in 51 patients vs. 22 matched healthy controls) of all four ILs during the acute phase. Especially for IL-4 this increase was statistically very significant (P < 0.001). Statistically marginally significant decrease was also observed for IL-10 concentrations (P < 0.059), for the two blood samples (acute phase and 2 weeks later). Conclusion: It is suggested by the present study that certain ILs might play an important role in the pathogenetic mechanism of urticaria. IL-4 and IL-10 participation seems to be relatively more significant. Possibly, ILs, liberated by mast cells, induce an influx of leukocytes in the dermis, therefore participating in the development of acute urticaria inflammation.J Clin Med Res. 2014;6(2):133-137 doi: http://dx.doi.org/10.14740/jocmr1645w
机译：背景：荨麻疹是一种皮肤病，会影响大约5％的普通人群，并且不仅表现为急性疾病，而且表现为慢性疾病。该疾病的病因及其临床表现从荨麻疹荨麻疹的存在扩展到潜在的致命性血管性水肿。不仅由于其特殊的临床表现，而且由于其致病机理，对该疾病引起了极大的兴趣。医学参考书目中的新数据支持白介素（ILs）参与荨麻疹的病理生理。该研究的目的是有助于理解某些ILs可能参与急性荨麻疹的发病机理。方法：我们的研究同时涉及四个ILs，IL-4，IL-6，IL-8和IL-10，以及在荨麻疹急性期以及给药后2周内它们的定量变化。此外，将患者的ILs水平与匹配的健康对照者的ILs水平进行了比较。所有测量均通过ELISA方法完成。统计分析由SPSS完成。结果：在急性期，所有四个IL的结果均升高（51位患者对比22位健康对照者）。特别是对于IL-4，这种增加在统计学上非常显着（P <0.001）。在两个血液样本（急性期和2周后）中，IL-10浓度也观察到统计学上的显着性降低（P <0.059）。结论：本研究提示某些IL可能在荨麻疹的发病机理中起重要作用。 IL-4和IL-10的参与似乎相对更重要。肥大细胞释放的ILs可能诱导真皮中白细胞的大量涌入，因此参与了急性荨麻疹炎症的发展。 2014; 6（2）：133-137 doi：http://dx.doi.org/10.14740/jocmr1645w

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