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首页> 外文期刊>Journal of Clinical Medicine >Association of Low Serum Adiponectin Levels with Aortic Arterial Stiffness in Patients with Type 2 Diabetes
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Association of Low Serum Adiponectin Levels with Aortic Arterial Stiffness in Patients with Type 2 Diabetes

机译：2型糖尿病患者低血清脂联素水平与主动脉僵硬度的关系

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Adiponectin, an anti-inflammatory and anti-atherogenic protein, affects glucose metabolism. High serum adiponectin levels are associated with decreased diabetes mellitus (DM) risks. Aortic arterial stiffness (AS) is associated with cardiovascular disease and mortality in type 2 DM patients. We assessed the association between adiponectin levels and aortic AS in type 2 DM patients. We measured serum adiponectin levels in 140 volunteers with type 2 DM and assigned patients with carotid–femoral pulse wave velocity (cfPWV) 10 m/s to the aortic AS group ( n = 54, 38.6%). These patients had higher systolic ( p = 0.001) and diastolic ( p = 0.010) blood pressures; body fat masses ( p = 0.041); serum triglyceride ( p = 0.026), phosphorus ( p = 0.037), and insulin ( p = 0.040) levels; and homeostasis model assessment of insulin resistance values ( p = 0.029) and lower estimated glomerular filtration rates ( p = 0.009) and serum adiponectin levels ( p = 0.001) than controls. Multivariable logistic regression analysis adjusted for confounders showed serum adiponectin levels (OR 0.922; 95% CI, 0.876–0.970; p = 0.002) as an independent predictor of aortic AS. Multivariable forward stepwise linear regression analyses showed that serum adiponectin levels (β = ?0.283, adjusted R 2 change: 0.054, p 0.001) were negatively associated with cfPWV. Thus, serum adiponectin level is an independent predictor of aortic AS in type 2 DM patients.
机译：脂联素是一种抗炎和抗动脉粥样硬化蛋白，会影响葡萄糖代谢。血清脂联素水平高与降低糖尿病（DM）风险有关。 2型DM患者的主动脉动脉僵硬度（AS）与心血管疾病和死亡率相关。我们评估了2型DM患者的脂联素水平与主动脉AS之间的关联。我们测量了140名2型DM志愿者的血清脂联素水平，并将其分配给主动脉AS组的颈动脉-股动脉脉搏波速度（cfPWV）> 10 m / s的患者（n = 54，38.6％）。这些患者的收缩压（p = 0.001）和舒张压（p = 0.010）较高;身体脂肪量（p = 0.041）;血清甘油三酸酯（p = 0.026），磷（p = 0.037）和胰岛素（p = 0.040）水平;胰岛素抵抗值（p = 0.029）和估计的肾小球滤过率（p = 0.009）和血清脂联素水平（p = 0.001）的动态平衡模型评估。校正混杂因素的多变量逻辑回归分析显示，血清脂联素水平（OR 0.922; 95％CI，0.876–0.970; p = 0.002）是主动脉AS的独立预测因子。多变量正向逐步线性回归分析表明，血清脂联素水平（β=±0.283，调整后的R 2变化：0.054，p <0.001）与cfPWV负相关。因此，血清脂联素水平是2型DM患者主动脉AS的独立预测因子。

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