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首页> 外文期刊>Journal of Clinical Medicine >Prevention of Bone Metastases in Breast Cancer Patients. Therapeutic Perspectives
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Prevention of Bone Metastases in Breast Cancer Patients. Therapeutic Perspectives

机译：预防乳腺癌患者的骨转移。治疗观点

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One in four breast cancer patients is at risk of developing bone metastases in her life time. The early prevention of bone metastases is a crucial challenge. It has been suggested that the use of zoledronic acid (ZOL) in the adjuvant setting may reduce the persistence of disseminated tumor cells and thereby might improve outcome, specifically in a population of patients with a low estrogen microenvironment. More recently, the results of a large meta-analysis from 41 randomized trials comparing a bisphosphonate (BP) to placebo or to an open control have been presented at the 2013 San Antonio Breast Cancer Meeting. Data on 17,016 patients confirm that adjuvant BPs, irrespective of the type of treatment or the treatment schedule and formulation (oral or intra-venously (IV)), significantly reduced bone recurrences and improved breast cancer survival in postmenopausal women. No advantage was seen in premenopausal women. BPs are soon likely to become integrated into standard practice. Published data on the mechanisms involved in tumor cell seeding from the primary site, in homing to bone tissues and in the reactivation of dormant tumor cells will be reviewed; these might offer new ideas for innovative combination strategies.
机译：四分之一的乳腺癌患者在其一生中有发生骨转移的风险。骨转移的早期预防是至关重要的挑战。已经提出在佐剂环境中使用唑来膦酸（ZOL）可以减少弥散性肿瘤细胞的持久性，从而可以改善结果，特别是在雌激素微环境低的患者群体中。最近，在2013年圣安东尼奥乳腺癌会议上提出了一项来自41个随机试验的大型荟萃分析结果，该试验比较了双磷酸盐（BP）与安慰剂或开放对照组的疗效。关于17016名患者的数据证实，无论治疗类型或治疗方案和配方（口服或静脉内（IV））如何，佐剂BP均可显着减少绝经后妇女的骨复发并改善乳腺癌的生存率。绝经前妇女没有优势。 BP很快可能会集成到标准实践中。将审查已发表的有关肿瘤细胞从原发部位播种，归巢到骨组织以及重新激活休眠的肿瘤细胞的机制的数据;这些可能会为创新的组合策略提供新的思路。

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