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首页> 外文期刊>Journal of Clinical Medicine >Impact of Cannabis Use on Treatment Outcomes among Adults Receiving Cognitive-Behavioral Treatment for PTSD and Substance Use Disorders
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Impact of Cannabis Use on Treatment Outcomes among Adults Receiving Cognitive-Behavioral Treatment for PTSD and Substance Use Disorders

机译：大麻使用对接受PTSD认知行为治疗和物质使用障碍的成年人的治疗效果的影响

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Background: Research has demonstrated a strong link between trauma, posttraumatic stress disorder (PTSD) and substance use disorders (SUDs) in general and cannabis use disorders in particular. Yet, few studies have examined the impact of cannabis use on treatment outcomes for individuals with co-occurring PTSD and SUDs. Methods: Participants were 136 individuals who received cognitive-behavioral therapies for co-occurring PTSD and SUD. Multivariate regressions were utilized to examine the associations between baseline cannabis use and end-of-treatment outcomes. Multilevel linear growth models were fit to the data to examine the cross-lagged associations between weekly cannabis use and weekly PTSD symptom severity and primary substance use during treatment. Results: There were no significant positive nor negative associations between baseline cannabis use and end-of-treatment PTSD symptom severity and days of primary substance use. Cross-lagged models revealed that as cannabis use increased, subsequent primary substance use decreased and vice versa. Moreover, results revealed a crossover lagged effect, whereby higher cannabis use was associated with greater PTSD symptom severity early in treatment, but lower weekly PTSD symptom severity later in treatment. Conclusion: Cannabis use was not associated with adverse outcomes in end-of-treatment PTSD and primary substance use, suggesting independent pathways of change. The theoretical and clinical implications of the reciprocal associations between weekly cannabis use and subsequent PTSD and primary substance use symptoms during treatment are discussed.
机译：背景：研究表明，创伤，创伤后应激障碍（PTSD）和一般物质使用障碍（SUD）之间，尤其是大麻使用障碍之间有着密切的联系。但是，很少有研究检查大麻的使用对PTSD和SUD并发患者治疗效果的影响。方法：参与者为136人，他们同时接受了PTSD和SUD的认知行为疗法。多变量回归用于检验基线大麻使用与治疗结束结局之间的关联。多级线性增长模型适合该数据，以检查治疗期间每周使用大麻与每周PTSD症状严重程度和主要药物使用之间的交叉滞后关联。结果：基线大麻使用与治疗结束后PTSD症状严重程度和主要药物使用天数之间没有显着的正相关或负相关。交叉滞后模型显示，随着大麻使用量增加，随后的主要物质使用量减少，反之亦然。此外，结果显示了交叉滞后效应，由此，较高的大麻使用量与治疗初期较高的PTSD症状严重程度相关，但在治疗后期较低的每周PTSD症状严重程度相关。结论：大麻的使用与治疗结束后PTSD和主要物质的使用没有不良后果，这表明变化的独立途径。讨论了在治疗期间每周使用大麻与随后的PTSD和主要物质使用症状之间的相互关系的理论和临床意义。

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