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首页> 外文期刊>Journal of Clinical Medicine Research >Toxoplasma gondii infection and premenstrual dysphoric disorder: a cross-sectional study
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Toxoplasma gondii infection and premenstrual dysphoric disorder: a cross-sectional study

机译：弓形虫感染和经前烦躁不安：横断面研究

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Background: Premenstrual dysphoric disorder is a severe form of premenstrual syndrome. The influence of?Toxoplasma gondii (T. gondii) infection on clinical features in women with this disorder has not been studied. Therefore, we determined the association of?T. gondii infection with symptoms and signs in women suffering from premenstrual dysphoric disorder.Methods: We performed a cross-sectional study of 151 women suffering from premenstrual dysphoric disorder. Anti-Toxoplasma IgG and IgM antibodies were detected in sera of the participants using enzyme-linked immunoassays (EIAs). In addition,?T. gondii DNA was detected in whole blood of IgG seropositive participants using polymerase chain reaction. We obtained the clinical data of women with the aid of a questionnaire. The association of?T. gondii infection with clinical characteristics of women was assessed by bivariate and multivariate analyses.Results: Anti-T. gondii IgG antibodies were found in 10 (6.6%) of the 151 women studied. Of the 10 IgG seropositive women, four (40.0%) were positive for anti-T. gondii IgM antibodies, and one (10.0%) for?T. gondii DNA. Mean number (25.8 ± 7.58) of premenstrual clinical characteristics in seropositive women was similar to that (29.22 ± 9.13) found in seronegative women (P = 0.25). Logistic regression showed that seropositivity to?T. gondii was negatively associated with difficulty concentrating (OR: 0.18; 95% CI: 0.03 - 0.91; P = 0.03), and positively associated with out of control feeling or overwhelmed (OR: 9.00; 95% CI: 1.32 - 62.00; P = 0.02).Conclusions: Results of this first study on the association of?T. gondii infection and clinical characteristics of premenstrual dysphoric disorder suggest that this infection might be linked to some symptoms of this disorder. We report for the first time the association of?T. gondiiinfection and out of control feeling or overwhelmed. Results warrant for further research on the role of?T. gondii in premenstrual dysphoric disorder.J Clin Med Res. 2016;8(10):730-736doi: http://dx.doi.org/10.14740/jocmr2699w
机译：背景：经前烦躁不安是经前综合症的一种严重形式。尚未研究弓形虫（T. gondii）感染对患有这种疾病的女性的临床特征的影响。因此，我们确定了ΔT的关联。方法：我们对151名经前烦躁症妇女进行了横断面研究。使用酶联免疫分析法（EIA）在参与者的血清中检测到抗弓形虫IgG和IgM抗体。另外，？使用聚合酶链反应在IgG血清反应阳性参与者的全血中检测到弓形虫DNA。我们借助问卷调查获得了女性的临床数据。的关联。通过双因素和多因素分析评估了具有临床特征的刚地犬感染。结果：抗-T。在研究的151位女性中，有10位（6.6％）发现了刚地IgG抗体。在10名IgG血清阳性妇女中，有4名（40.0％）抗T阳性。刚地IgM抗体和一种（10.0％）for？T。刚地DNA。血清反应阳性妇女的经前临床特征平均数（25.8±7.58）与血清反应阴性妇女的经前平均临床特征数（29.22±9.13）相似（P = 0.25）。 Logistic回归显示血清对？T呈阳性。刚地犬与注意力不集中呈负相关（OR：0.18; 95％CI：0.03-0.91; P = 0.03），与失控或不知所措呈正相关（OR：9.00; 95％CI：1.32-62.00; P = 0.02）。结论：这项关于？T关联的首次研究的结果。刚地氏菌感染和经前烦躁不安的临床特征表明，这种感染可能与该病症的某些症状有关。我们第一次报告T的关联。刚地感染并失去控制的感觉或不知所措。结果值得进一步研究？T的作用。刚地痛的经前障碍。临床医学杂志。 2016; 8（10）：730-736doi：http://dx.doi.org/10.14740/jocmr2699w

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