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首页> 外文期刊>Journal of Clinical Medicine Research >Urate-Lowering Therapy Ameliorates Kidney Function in Type 2 Diabetes Patients With Hyperuricemia
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Urate-Lowering Therapy Ameliorates Kidney Function in Type 2 Diabetes Patients With Hyperuricemia

机译：降低尿酸的疗法可改善2型糖尿病高尿酸血症患者的肾脏功能

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Background: Hyperuricemia often causes kidney dysfunction which increases serum urate, forming a vicious cycle in the kidney. In this study, urate-lowering therapy was demonstrated in type 2 diabetic patients with hyperuricemia to evaluate the effect on diabetic nephropathy.Methods: Type 2 diabetic patients with hyperuricemia (n = 34) were treated by urate-lowering drugs. Serum urate levels, estimated glomerular filtration rate (eGFR), blood pressure, HbA1c, and urinary albumin-to-creatinine ratio (UACR) were measured for 52 weeks. The parameters at the endpoint when serum urate decreased to below 6.0 mg/dL and at 52 weeks were compared to the initial levels at week 0.Results: Serum urate level decreased to the endpoint in all patients and was maintained at under 6.0 mg/dL throughout the observation period. eGFR significantly increased at the endpoint and also at 52 weeks. Overall UACR did not change after 52 weeks; however, the treatment decreased UACR significantly in patients with no microalbuminuria. There was a negative relationship between the change of serum urate levels and the change of eGFR, and a negative relationship between the baseline UACR and the change of UACR when patients with macroalbuminuria were excluded. There were no changes in HbA1c levels and blood pressure before and after the treatment.Conclusions: There were significant improvements in kidney function by lowering serum urate levels to under 6.0 mg/dL and the effect was maintained for at least 52 weeks. This treatment may be one strategy to slow the progression of nephropathy in type 2 diabetic patients with hyperuricemia.J Clin Med Res. 2017;9(12):1007-1012doi: https://doi.org/10.14740/jocmr3219w
机译：背景：高尿酸血症通常会导致肾功能不全，从而增加血清尿酸，在肾脏中形成恶性循环。本研究在2型糖尿病高尿酸血症患者中证实了降尿酸盐治疗以评估其对糖尿病肾病的影响。方法：对2型糖尿病高尿酸血症患者（n = 34）进行降尿酸药物治疗。测量52周的血清尿酸水平，估计的肾小球滤过率（eGFR），血压，HbA1c和尿白蛋白与肌酐的比率（UACR）。将血清尿酸盐降至低于6.0 mg / dL时和52周时终点的参数与第0周时的初始水平进行比较。结果：所有患者的血清尿酸盐水平均降至终点，并保持在6.0 mg / dL以下在整个观察期间。终点和52周时eGFR显着增加。 UACR总体在52周后没有变化。然而，在没有微量白蛋白尿的患者中，治疗显着降低了UACR。排除大白蛋白尿患者时，血清尿酸水平变化与eGFR变化呈负相关，基线UACR与UACR变化呈负相关。治疗前后HbA1c水平和血压均无变化。结论：将血清尿酸水平降低至6.0 mg / dL以下，可显着改善肾脏功能，并维持至少52周。这种治疗可能是减缓2型糖尿病高尿酸血症患者肾病进展的一种策略。 2017; 9（12）：1007-1012doi：https://doi.org/10.14740/jocmr3219w

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