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首页> 外文期刊>Journal of Clinical Medicine Research >Treatment of Severe Poison Ivy: A Randomized, Controlled Trial of Long Versus Short Course Oral Prednisone
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Treatment of Severe Poison Ivy: A Randomized, Controlled Trial of Long Versus Short Course Oral Prednisone

机译：重度常春藤的治疗：长对短疗程口服泼尼松的随机对照试验

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Background: Toxidendron (poison ivy, oak, and sumac) contact dermatitis is a common complaint in the outpatient primary care setting with little evidence-based guidance on best treatment duration. Methods: This randomized, controlled trial examined the efficacy and side effects of a 5-day regimen of 40 mg oral prednisone daily (short course) compared to the same 5-day regimen followed by a prednisone taper of 30 mg daily for 2 days, 20 mg daily for 2 days, 10 mg daily for 2 days, and 5 mg daily for 4 days over a total of 15 days (long course) in patients with severe poison ivy dermatitis. Results: In 49 patients with severe poison ivy, non-adherence rates, rash return, medication side effects, and time to improvement and complete healing of the rash were not significantly different between the two groups. Patients receiving the long course regimen were significantly less likely to utilize other medications (22.7% vs. 55.6%, P = 0.02, number needed to treat 3.05). Conclusions: This study suggests that a longer course prescription may save patients’ time and exposure to excess medication in the treatment of severe poison ivy. Application of this information to clinical practice will save return visits and reduce excess non-prescription medication administration to individual patients.J Clin Med Res. 2014;6(6):429-434doi: http://dx.doi.org/10.14740/jocmr1855w
机译：背景：苯双胍（毒藤，橡树和漆树）接触性皮炎是门诊初级保健环境中的常见病，几乎没有关于最佳治疗持续时间的循证指南。方法：这项随机对照试验研究了每天40 mg口服泼尼松5天方案（短期疗程）与相同的5天方案，然后泼尼松锥度30 mg每天2天的疗效和副作用，对于重度常春藤皮炎患者，在总共15天（长疗程）中，每天20 mg，连续2天，每天10 mg，连续2天，每天5 mg，连续4天。结果：在49名重症常春藤患者中，两组之间的不依从率，皮疹复发，药物副作用以及皮疹的改善和完全治愈时间没有显着差异。接受长期疗程的患者使用其他药物的可能性大大降低（22.7％vs. 55.6％，P = 0.02，需要治疗的数量3.05）。结论：这项研究表明，较长疗程的处方可以节省重症常春藤的治疗时间，并节省患者的时间。将此信息应用于临床实践将节省回诊次数，并减少对个别患者的过量非处方药管理。JClin Med Res。 2014; 6（6）：429-434doi：http：//dx.doi.org/10.14740/jocmr1855w

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