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首页> 外文期刊>Journal of Clinical Medicine Research >Association of Glycosylated Hemoglobin Levels With Vitamin D Status
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Association of Glycosylated Hemoglobin Levels With Vitamin D Status

机译：糖基化血红蛋白水平与维生素D状态的关联

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Background: The discovery of vitamin D is one of medicine’s great achievements. Despite all the positive evidence emerging about the beneficial effect of vitamin D, we still find many are vitamin D deficient. The purposes of this study were to examine the association between serum 25-hydroxyvitamin D (25(OH)D) and glycosylated hemoglobin (HbA1c) levels, to test the hypothesis that lower 25(OH)D levels are associated with poorer glucose control in diabetes mellitus (DM) patients and to investigate the effect of vitamin D supplementation on HbA1c levels.Methods: This was a prospective observational cohort study of all patients with type 1 and type 2 diabetes (above 12 years) who attended the outpatient clinics of a tertiary center in Riyadh. HbA1c and vitamin D levels were recorded prior to supplementation and after 9 months of supplementation with vitamin D. All patients were divided into four groups according to their vitamin D level and an association between 25(OH)D and HbA1c was tested.Results: Results showed that 73.1% of the patients had 25(OH)D levels < 50 nmol/L. We observed lowering of HbA1c after vitamin D supplementation (from mean HbA1c of 10.55 to 7.70). We found HbA1c to be inversely related to serum vitamin D levels (r = -0.14 (P < 0.0000002) before supplementation and -0.16 (P < 0.000001) after supplementation with vitamin D).Conclusions: Advising patients with higher HbA1c to test their vitamin D level and correct any deficiency will result in better blood glucose control and benefit the patient’s overall health.J Clin Med Res. 2017;9(12):1013-1018doi: https://doi.org/10.14740/jocmr3227w
机译：背景：维生素D的发现是医学的一项重大成就。尽管出现了有关维生素D有益作用的所有积极证据，但我们仍然发现许多维生素D缺乏。这项研究的目的是检查血清25-羟基维生素D（25（OH）D）与糖基化血红蛋白（HbA1c）水平之间的关联，以检验以下假设：较低的25（OH）D水平与血糖控制较差有关。方法：这是对所有就诊于门诊就诊的1型和2型糖尿病（12岁以上）患者的前瞻性观察性队列研究。利雅得第三中心。在补充维生素D之前和补充维生素D 9个月后记录HbA1c和维生素D的水平。根据患者的维生素D水平将所有患者分为四组，并测试25（OH）D与HbA1c之间的相关性。结果：结果结果显示73.1％的患者25（OH）D水平<50 nmol / L。我们观察到补充维生素D后HbA1c降低（从平均HbA1c从10.55到7.70）。我们发现HbA1c与血清维生素D水平呈负相关（补充前r = -0.14（P <0.0000002），补充维生素D后r -0.16（P <0.000001））。结论：建议HbA1c较高的患者测试维生素D水平并纠正任何缺乏症将导致更好的血糖控制并有益于患者的整体健康。JClin Med Res。 2017; 9（12）：1013-1018doi：https://doi.org/10.14740/jocmr3227w

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