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首页> 外文期刊>Journal of Clinical Medicine Research >Treatment of Burning Mouth Syndrome With Amisulpride
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Treatment of Burning Mouth Syndrome With Amisulpride

机译：氨磺必利治疗烧灼综合征

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Background: Burning mouth syndrome (BMS) is a frequently occurring disease characterized by a burning or painful sensation in the tongue and/or other oral sites without clinical mucosal abnormalities or lesions. Its etiopathology is unknown, although local, systemic, and psychological factors have been associated with BMS. The syndrome is multifactorial, and its management remains unsatisfactory. The purpose of this study was to obtain preliminary data regarding the efficacy and tolerability of amisulpride in BMS treatment.?Methods: The subjects were treated with amisulpride (50 mg/day) for 24 weeks. Efficacy assessment included a visual analogue scale (VAS) for pain intensity, the Hamilton Rating Scale for Depression (HAM-D), the Hamilton Rating Scale for Anxiety (HASM-A), and the Clinical Global Impression Scale-Efficacy Index (CGI-EI).?Results: The treatment regimens resulted in a significant improvement in burning mouth symptoms from baseline at week 24, as indicated by the quantitative mean illness duration VAS score, HAM-D, and HAM-A. Amisulpride appears to be effective and patients show a rapid response to treatment. No serious adverse effects were encountered in these patients.?Conclusion: Amisulpride is effective and well tolerated as a short-term treatment. It is particularly efficacious at the start of treatment and has shorter response latency. Double-blind placebo-controlled trials are needed for further assessment of the efficacy of amisulpride in BMS treatment.doi:10.4021/jocmr972w
机译：背景：烧嘴综合症（BMS）是一种经常发生的疾病，其特征是舌头和/或其他口腔部位有烧灼感或疼痛感，而没有临床粘膜异常或病变。尽管局部，全身和心理因素与BMS相关，但其病因仍未知。该综合征是多因素的，其治疗仍不令人满意。这项研究的目的是获得有关氨磺必利在BMS治疗中的疗效和耐受性的初步数据。方法：受试者接受氨磺必利（50毫克/天）治疗24周。功效评估包括疼痛强度的视觉模拟量表（VAS），汉密尔顿抑郁量表（HAM-D），汉密尔顿焦虑量表（HASM-A）和临床总体印象量表效能指数（CGI-结果：治疗方案导致从第24周开始的灼伤口腔症状与基线相比有明显改善，如定量平均病程VAS评分，HAM-D和HAM-A所表明的。氨磺必利似乎有效，患者对治疗表现出快速反应。这些患者没有遇到严重的不良反应。结论：氨磺必利作为短期治疗有效且耐受性良好。它在治疗开始时特别有效，并且反应潜伏期较短。需要双盲安慰剂对照试验以进一步评估氨磺必利在BMS治疗中的疗效.doi：10.4021 / jocmr972w

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