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首页> 外文期刊>Journal of Clinical Medicine Research >The Impact of Thiamine Treatment in the Diabetes Mellitus
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The Impact of Thiamine Treatment in the Diabetes Mellitus

机译：硫胺素治疗对糖尿病的影响

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Thiamine acts as a coenzyme for transketolase (Tk) and for the pyruvate dehydrogenase and α-ketoglutarate dehydrogenase complexes, enzymes which play a fundamental role for intracellular glucose metabolism. The relationship between thiamine and diabetes mellitus (DM) has been reported in the literature. Thiamine levels and thiamine-dependent enzyme activities have been reduced in DM. Genetic studies provide opportunity to link the relationship between thiamine and DM (such as Tk, SLC19A2 gene, transcription factor Sp1, α-1-antitrypsin, and p53). Thiamine and its derivatives have been demonstrated to prevent the activation of the biochemical pathways (increased flux through the polyol pathway, formation of advanced glycation end-products, activation of protein kinase C, and increased flux through the hexosamine biosynthesis pathway) induced by hyperglycemia in DM.Thiamine definitively has a role in the diabetic endothelial vascular diseases (micro and macroangiopathy), lipid profile, retinopathy, nephropathy, cardiopathy, and neuropathy.doi:10.4021/jocmr890w
机译：硫胺素是转酮醇酶（Tk）和丙酮酸脱氢酶和α-酮戊二酸脱氢酶复合物的辅酶，这些酶在细胞内葡萄糖代谢中起重要作用。硫胺素与糖尿病（DM）之间的关系已有文献报道。 DM中硫胺素水平和硫胺素依赖性酶活性已降低。遗传研究提供了联系硫胺素和DM（例如Tk，SLC19A2基因，转录因子Sp1，α-1-抗胰蛋白酶和p53）之间关系的机会。硫胺素及其衍生物已被证明可防止高血糖症引起的生化途径的激活（通过多元醇途径的通量增加，高级糖基化终产物的形成，蛋白激酶C的活化以及通过己胺生物合成途径的通量的增加）。 DM。硫胺素在糖尿病内皮血管疾病（微血管病变和大血管病变），脂质分布，视网膜病变，肾病，心脏病和神经病变中具有决定性作用.doi：10.4021 / jocmr890w

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