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首页> 外文期刊>Journal of Clinical Medicine Research >Ultrastructural Changes in Rat’s Atrial Cardiomyocytes After Short Term Administration of Amiodarone and Possible Protective Role of Vitamin E
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Ultrastructural Changes in Rat’s Atrial Cardiomyocytes After Short Term Administration of Amiodarone and Possible Protective Role of Vitamin E

机译：短期给予胺碘酮对大鼠心房心肌细胞超微结构的影响以及维生素E的保护作用

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Background: Amiodarone chlorhydrate is a diiodated benzofuran derivative used to treat a variety of cardiac rhythm abnormalities. The use of amiodarone is associated with ultrastructural changes affecting body tissues, but its effect on the ultrastructure of the heart has not yet been fully elucidated.?Methods: The aim of this study is to test the adverse effects of amiodarone administration on cardiomyocytes and to study the possible protective role of vitamin E co-administration. A total of 18 adult male albino rats were used in this study. The rats were divided randomly into three groups of 6 rats each as follows: group I was considered the control group and was given vegetable oil; group II received 54 mg/kg of oral amiodarone; and group III received a single dose of combined vitamin E (50 mg/kg) and amiodarone (54 mg/kg). After 2 weeks, the rats were sacrificed, and the atrial tissues were harvested and processed for electron microscopic study.?Results: Administration of amiodarone alone modified the atrial architecture, which was demonstrated by the following: mitochondrial enlargement and cristae lysis; marked heterogeneity of myofibril patterns with partial necrosis and disintegration of myofilaments; and irregularities of the sarcomere and less concentration of atrionatriuretic factor (ANF) granules, which localised in closed proximity to the nucleus with disrupted chromatin contents. Concomitant administration of vitamin E with amiodarone showed a considerable preservation of the atrial architecture. Conclusion: Oral administration of amiodarone in rats resulted in ultrastructural changes in atria, which can be attenuated by vitamin E co-administration.doi:10.4021/jocmr909w
机译：背景：盐酸胺碘酮是一种二碘代苯并呋喃衍生物，用于治疗各种心律异常。胺碘酮的使用与影响身体组织的超微结构改变有关，但尚未完全阐明其对心脏超微结构的影响。方法：本研究的目的是检验胺碘酮对心肌细胞的不良影响，并研究维生素E并用的可能的保护作用。本研究共使用18只成年雄性白化病大鼠。将大鼠随机分为三组，每组六只，如下：第一组被认为是对照组并给予植物油。第II组口服54 mg / kg口服胺碘酮;第三组接受了单剂量的维生素E（50 mg / kg）和胺碘酮（54 mg / kg）的联合治疗。 2周后处死大鼠，取房组织，进行电镜观察。结果：单独应用胺碘酮可改变心房结构，表现为线粒体扩大和enlarge裂。肌原纤维模式明显异质性，部分肌丝坏死和崩解;肌小节的不规则性以及较少的浓度的心钠素（ANF）颗粒，这些颗粒紧密地位于细胞核附近，染色质含量受损。维生素E和胺碘酮的同时给药显示出对心房结构的相当大的保护。结论：口服胺碘酮可导致心房超微结构改变，维生素E共同给药可减轻这种变化。doi：10.4021 / jocmr909w

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