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首页> 外文期刊>Journal of Clinical Medicine and Research >Preliminary experience of the clinical and tomographic characteristics of patients with non-refractory acute respiratory insufficiency caused by H1N1 influenza, a virus infection and disease intervention
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Preliminary experience of the clinical and tomographic characteristics of patients with non-refractory acute respiratory insufficiency caused by H1N1 influenza, a virus infection and disease intervention

机译：由H1N1流感，病毒感染和疾病干预引起的非难治性急性呼吸道功能不全患者的临床和断层扫描特征的初步经验

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The HIN1 influenza A virus infection has spread rapidly worldwide, and although it is believed to have a low mortality rate, once the virus reaches the acute refractory respiratory insufficiency phase, the mortality rate increases drastically. This study reports the results of 10 clinical case studies; the patients presented signs and symptoms of acute respiratory insufficiency and were positive for the H1N1 influenza A virus. The characteristics of the patients were the following: mean age was 28.5 ± 15.4 SD., the mean time of patient hospitalization was 12.5 days ± 10.9 SD., the mean values of interleukin 6 were: 17.8 ± 9.9 SD., the mean level of SaO2% was 91.3 ± 2.5 SD., the mean values for respiratory frequency were 28.8 ± 4.2 SD., and the mean values of arterial PO2?were 59.99 ± 9. The most frequent findings on high resolution computerized tomography findings were the thickening of the peribronchovascular space (90%), followed by intralobular septa thickening (50%), subpleural septa thickening (30%), bronchioectasis (40%), mosaic image of perfusion (40%), and pulmonary condensation zones (30%). Two patients required non-invasive mechanical ventilation that was set to a low exhaled tidal volume of 200 ml for the patient weighing 42 kg and 300 ml for the patient weighing 60 kg.? The findings on the HRCT in these patients represent a precocious interstitial lung lesion. The authors believe that an early intervention could prevent the disease progression and the onset of the refractory phase that subsequently leads to hypoxemia and diffuse alveolar damage.
机译：HIN1甲型流感病毒感染已在世界范围内迅速传播，尽管据认为其死亡率很低，但是一旦病毒进入急性难治性呼吸功能不全阶段，死亡率就会急剧上升。这项研究报告了10个临床案例研究的结果;患者表现出急性呼吸功能不全的症状和体征，并且H1N1甲型流感病毒呈阳性。患者的特征如下：平均年龄为28.5±15.4 SD。，平均住院时间为12.5天±10.9 SD。，白介素6的平均值为：17.8±9.9 SD。，平均水平。 SaO2％为91.3±2.5 SD。，呼吸频率的平均值为28.8±4.2 SD。，动脉PO2？的平均值为59.99±9。支气管血管周围空间（90％），其次是小叶内隔增厚（50％），胸膜下隔增厚（30％），支气管扩张（40％），灌注马赛克图像（40％）和肺部凝结区（30％）。两名患者需要无创机械通气，对于体重42公斤的患者，呼气潮气设定为低200毫升，对于体重60公斤的患者，呼气潮气设定为300毫升。在这些患者中，HRCT的发现代表了早熟的间质性肺病变。作者认为，早期干预可以预防疾病进展和难治期的发作，难治期随后导致低氧血症和弥漫性肺泡损伤。

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