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首页> 外文期刊>Journal of Clinical Medicine and Research >Haematological changes and recovery associated with treated and untreated Plasmodium falciparum infection in children in the Mount Cameroon Region
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Haematological changes and recovery associated with treated and untreated Plasmodium falciparum infection in children in the Mount Cameroon Region

机译：喀麦隆山地区儿童治疗和未治疗的恶性疟原虫感染的血液学变化和恢复

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Pre-hospital antimalarial treatment of febrile children remains a significant common practice among individuals in the Mount Cameroon region. To evaluate the effect of routinely administered monotherapy sulphadoxine pyrimethamine (SP), treatment using amodiaquine artesunate (AQAS) combination therapy and untreated malaria on haematological and parasitological parameters, 332 malaria positive subjects were assigned to three groups comprising 138 children treated with AQAS, 43 treated with SP and 151 untreated. The changes and recovery in red cell indices, white blood cell and differential and platelets counts were compared. The highest haematological recovery (39.1%) occurred in the AQAS treatment group. The majority (94%) of the untreated cases never achieved haematological recovery even though there was spontaneous clearance of parasites in some cases. Haematological insult was greatest in untreated children followed by those treated with SP, the 1.1 - 3 year age group whether or not they received treatment and in those with high parasitaemia. Delayed parasite clearance observed in the untreated and SP treatment group may be responsible for the occurrence of haematological insult. Treatment type and parasitological cure was associated with haematological recovery. Prompt use of effective arthemisinin combination therapy reduced the burden of malaria, hence the greater clinical and haematological benefits observed in our study.
机译：在喀麦隆山地区的人们中，发热儿童的院前抗疟疾治疗仍然是一种重要的普遍做法。为了评估常规单药治疗的磺胺多辛嘧啶胺（SP），青蒿琥酯氨氮喹啉（AQAS）联合治疗和未治疗的疟疾对血液学和寄生虫学参数的影响，将332例疟疾阳性受试者分为三组，包括138例接受AQAS治疗的儿童，43例接受了治疗SP和151未经处理。比较了红细胞指数，白细胞以及差异和血小板计数的变化和恢复。 AQAS治疗组的血液学恢复最高（39.1％）。大多数未经治疗的病例（94％）从未达到血液学恢复，即使在某些情况下可以自发清除寄生虫。在未经治疗的儿童中，血液学损害最大，其次是接受SP治疗的儿童（1.1-3岁年龄组，无论是否接受治疗）和寄生虫血症高的儿童。未经治疗和SP治疗组中观察到的寄生虫清除延迟可能是血液学损伤的发生原因。治疗类型和寄生虫学治愈与血液学恢复有关。及时使用有效的青蒿素联合疗法可减轻疟疾的负担，因此在我们的研究中观察到了更大的临床和血液学益处。

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