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首页> 外文期刊>Journal of Clinical Medicine and Research >Antimicrobial susceptibility of some respiratory tract pathogens to commonly used antibiotics at the Specialist Hospital, Yola, Adamawa State, Nigeria
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Antimicrobial susceptibility of some respiratory tract pathogens to commonly used antibiotics at the Specialist Hospital, Yola, Adamawa State, Nigeria

机译：尼日利亚阿达玛瓦州约拉专科医院某些呼吸道病原体对常用抗生素的抗菌敏感性

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The study was aimed at determining the prevalence and antibacterial susceptibility of bacterial strains isolated from the respiratory tract of patients attending the major hospital in Yola, Nigeria. The study was carried out between January, 2008 - June, 2009. Sputum, throat and mouth specimens were collected and cultured on the appropriate bacteriological media. Bacterial isolates were identified by standard biochemical tests. Antimicrobial susceptibility testing was performed according to Clinical and Laboratory Standard Institute (CLSI) guidelines. Of the samples analyzed, some 232 species of various bacteria were isolated, giving a prevalence rate of?92.8%. This consisted of?49.1% from male patients and 50.9% from females. The bacteria isolated from the samples included??Streptococcus pyogens?(22.4%),Streptococcus pneumoniae?(21.6%),?Staphylococcus aureus?(19.0%),?Klebsiella pneumoniae?(11.2%), and?Haemophilus influenza?(10.3%),?Proteus mirabilis?(8.6%) and?Pseudomonas aeruginosa?(6.9%) in order of ranking. All the isolates were susceptible to ciprofloxacin, ofloxacin and ceftriazone, moderately susceptible to chloramphenicol, erythromycin, colistin, nitrofurantoin and nalidixic acid and resistant to gentamycin, ampicillin, tetracycline, co-trimoxazole, streptomycin and penicillin.?S. aureus?was the most susceptible amongst the isolates. Penicillin had the highest resistance to all the isolates. Most of the isolates were displayed by multi-drug resistance with?P. aeruginosa and H. influenzae?showing the highest number of multi-drug resistance to most of the antibiotics except the fluoroquinolones. Although, multi-drug resistant strains of organisms?were identified, ciprofloxacin, ofloxacin and ceftriazone are recommended as?antibiotics of choice against the pathogens. These findings have clinical and epidemiological significance.
机译：这项研究的目的是确定从在尼日利亚约拉的主要医院就诊的患者的呼吸道分离出的细菌菌株的患病率和抗菌药敏性。该研究在2008年1月至2009年6月之间进行。收集痰液，喉咙和口腔标本，并在适当的细菌培养基上进行培养。细菌分离株通过标准生化试验鉴定。根据临床和实验室标准协会（CLSI）指南进行了抗生素敏感性测试。在所分析的样品中，分离出约232种各种细菌，患病率达92.8％。其中男性患者占49.1％，女性占50.9％。从样本中分离出的细菌包括化脓性链球菌（22.4％），肺炎链球菌（21.6％），金黄色葡萄球菌（19.0％），肺炎克雷伯菌（11.2％）和流感嗜血杆菌（10.3）。 ％），奇异变形杆菌（8.6％）和铜绿假单胞菌（6.9％）。所有分离株均对环丙沙星，氧氟沙星和头孢曲松敏感，对氯霉素，红霉素，大肠菌素，硝基呋喃妥因和萘啶酸敏感，对庆大霉素，氨苄青霉素，四环素，复方莫沙唑，链霉素和青霉素有抗性。金黄色葡萄球菌是分离株中最易感的。青霉素对所有分离株的耐药性最高。大多数分离株表现出对？P的多重耐药性。铜绿假单胞菌和流感嗜血杆菌对除氟喹诺酮类药物外的大多数抗生素的多重耐药性最高。尽管已鉴定出对生物具有多重耐药性的菌株，但仍建议环丙沙星，氧氟沙星和头孢特里亚作为对病原体的首选抗生素。这些发现具有临床和流行病学意义。

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