...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Clinical Medicine Research >High Total Bilirubin as a Protective Factor for Diabetes Mellitus: An Analysis of NHANES Data From 1999 - 2006
【24h】

High Total Bilirubin as a Protective Factor for Diabetes Mellitus: An Analysis of NHANES Data From 1999 - 2006

机译：高总胆红素作为糖尿病的保护因子：1999-2006年NHANES数据分析

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background: Diabetes Mellitus (DM) is a rampantly growing epidemic in the United States, affecting nearly 10% of the adult population. Studies have shown that higher levels of Total Bilirubin (TBili) convey a protective effect with regard to cardiovascular risk. In this study, we will examine the relationship between TBili level and prevalence of DM to discern whether a similar relationship exists.Methods: The National Health and Nutrition Examination Survey (NHANES) is a comprehensive survey performed regularly to evaluate the overall health and nutrition status of the United States population. For the purpose of this study, we combined NHANES data collected between 1999 and 2006. Totally 15,876 eligible participants were selected after excluding all patients younger than twenty years, those with a history of abnormal liver function tests, or those who disclosed a history of liver disease. The data collected on these individuals was adjusted for demographic characteristics, as well as risk factors for DM, and was analyzed via multivariate logistic regression, using SAS proc survey methodology. Results: After age adjustment, increased TBili was associated with 26% reduction in diabetes risk (OR 0.74, 95% CI 0.64 - 0.88). Multivariate analysis, adjusting for all diabetes risk factors assessed, confirmed this association (OR 0.80, 95% CI 0.67 - 0.95). Conclusions: Our results show that a higher level of serum TBili is associated with odds of having a lower incidence of DM. This finding supports the hypothesis that the antioxidant nature of TBili, demonstrating a protective effect with regard to the risk of stroke, atherosclerosis, and vasculitis in prior research, also extends to DM risk. Furthermore, research has shown that higher levels of TBili increase glucose mobilization into the cells, leading to more efficient, biologic glucose utilization. There is no doubt that the beneficial effect of TBili is multifactorial; thus further investigation is warranted.?doi:10.4021/jocmr425w
机译：背景：糖尿病（DM）在美国是一种流行病，正在蔓延，影响了近10％的成年人口。研究表明，较高的总胆红素（TBili）水平可预防心血管疾病。在这项研究中，我们将检查TBili水平与DM患病率之间的关系，以判断是否存在类似的关系。方法：全国健康和营养检查调查（NHANES）是一项定期进行的综合调查，以评估总体健康和营养状况美国人口。出于这项研究的目的，我们结合了1999年至2006年收集的NHANES数据。在排除所有20岁以下，有肝功能异常检查史或有肝病史的患者后，总共选择了15876名合格参与者。疾病。对这些个体收集的数据进行了人口统计学特征以及DM危险因素的调整，并使用SAS proc调查方法通过多因素logistic回归进行了分析。结果：调整年龄后，TBili升高与糖尿病风险降低26％有关（OR 0.74，95％CI 0.64-0.88）。对所有评估的糖尿病危险因素进行调整后的多变量分析证实了这一关联（OR 0.80，95％CI 0.67-0.95）。结论：我们的结果表明，较高的血清TBili水平与DM发生率较低的可能性有关。这一发现支持了以下假设：TBili的抗氧化性质在先前研究中显示出对中风，动脉粥样硬化和血管炎风险的保护作用，也扩展到DM风险。此外，研究表明，较高的TBili水平会增加葡萄糖向细胞内的迁移，从而提高生物葡萄糖的利用效率。毫无疑问，TBili的有益作用是多方面的。 doi：10.4021 / jocmr425w

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号