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首页> 外文期刊>Journal of Clinical Medicine Research >Impact of Drug Induced Long QT Syndrome: A Systematic Review
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Impact of Drug Induced Long QT Syndrome: A Systematic Review

机译：药物诱导的长QT综合征的影响：系统评价

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Background: Drug induced long QT syndrome is quite common in daily clinical practice but its impact is unknown.Methods: PubMed and EMBASE databases (until May 2, 2017) were searched to identify studies reporting drug induced long QT syndrome and followed the PRISMA guidelines. The main outcomes measured in these studies were QTc prolongation, ventricular arrhythmias, torsade de pointes (TdP) and death.Results: Out of 176 non-duplicate reports, 36 studies satisfied inclusion criteria and provided data on patients exposed to drugs that can potentially cause long QT. Totally, 14,756 patients were exposed and 930 patients (6.3%) were found to have QTc prolongation. The number of males was 6,400 and females were 5,723 patients. The mean age of the patients was 43.8 ± 9.36 years. Ventricular arrhythmias were found in 379 patients (2.6%), 26 patients were found to have premature atrial contractions (PACs) and premature ventricular contractions (PVCs). TdP was found in 49 patients (0.33 %), sudden cardiac death (SCD) was found in five patients and 586 patients were found to have all-cause mortality.Conclusions: Around 6% of patients have risk of QT prolongation when exposed but only 0.3% developed TdP and 2.6% developed ventricular arrhythmias. Risk of developing arrhythmias is higher with concomitant use of multiple QT prolonging drugs.J Clin Med Res. 2018;10(5):384-390doi: https://doi.org/10.14740/jocmr3338w.
机译：背景：药物诱发的长QT综合征在日常临床实践中很普遍，但其影响尚不清楚。方法：检索PubMed和EMBASE数据库（至2017年5月2日），以鉴定报告药物诱发的长QT综合征并遵循PRISMA指南的研究。这些研究的主要结局是QTc延长，室性心律失常，扭转性躯干（TdP）和死亡。结果：在176项无重复的报告中，有36项研究符合纳入标准，并提供了暴露于可能引起疾病的药物的患者的数据。长QT。总共有14,756名患者被暴露，发现930名患者（6.3％）患有QTc延长。男性为6,400例，女性为5,723例。患者的平均年龄为43.8±9.36岁。 379例（2.6％）发现室性心律失常，发现26例发生房性早搏（PACs）和室性早搏（PVCs）。 49例患者（0.33％）发现了TdP，5例发现心脏性猝死（SCD），586例具有全因死亡率。结论：大约6％的患者在暴露时有QT延长的风险，但仅0.3％的患者发生了TdP，2.6％的患者出现了室性心律失常。伴随使用多种延长QT的药物，发生心律不齐的风险更高.J Clin Med Res。 2018; 10（5）：384-390doi：https://doi.org/10.14740/jocmr3338w。

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