Highlights ? Youth-onset severe obesity warrants particular concern in urban female populations. ? Among 2226 girls, prevalence was 8.3% at age 7–10, 10.8% at age 12–15 and fairly stable over teen years. ? Severe obesity prevalence increased more rapidly with age for girls born in 1995 versus 1992. ? Severely obese girls' BMI grew 2.6 times as fast as normal-BMI peers in the transition to adolescence. ? Late childhood and early adolescence is a key developmental window for prevention and treatment. Abstract Objective To understand the incidence and persistence of severe obesity (≥1.2?×?95th BMI percentile-for-age) in girls across the transition to adolescence, and map developmental trajectories of adolescent severe obesity in a high-risk sample. Methods We examined ten years of prospectively collected data from a population sample of urban girls (n?=?2226; 53% African American, aged 7–10 in 2003–2004). We determined severe obesity prevalence and incidence by age. Logistic regression evaluated for secular trend in the association between age and severe obesity prevalence. Unconditional latent growth curve models (LGCMs) compared BMI development through the adolescence transition between girls with severe obesity versus healthy BMI. Results Severe obesity prevalence was 8.3% at age 7–10 and 10.1% at age 16–19 (white: 5.9%; African American: 13.2%; p?
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机译：强调 ？青年发病的严重肥胖值得城市女性人群特别关注。 ？在2226名女孩中，患病率在7-10岁时为8.3％，在12-15岁时为10.8％，在青少年时期相当稳定。 ？与1992年相比，1995年出生的女孩的严重肥胖患病率随着年龄的增长而增长更快。在过渡到青春期期间，严重肥胖的女孩的BMI增长速度是正常BMI同行的2.6倍。 ？儿童晚期和青春期早期是预防和治疗的关键发展窗口。摘要目的了解严重肥胖症（≥1.2？×？95th BMI年龄百分比）在发病至青春期的发生率和持续性，并绘制高危样本中青少年严重肥胖症的发展轨迹。方法我们检查了十年前瞻性收集的城市女童样本数据（n = 2226; 53％的非洲裔美国人，2003-2004年为7-10岁）。我们根据年龄确定了严重的肥胖患病率和发病率。 Logistic回归评估了年龄与严重肥胖患病率之间关系的长期趋势。无条件潜伏生长曲线模型（LGCM）比较了严重肥胖女孩与健康BMI之间青春期过渡期间BMI的发展。结果严重肥胖发生率在7-10岁时为8.3％，在16-19岁时为10.1％（白人：5.9％;非裔美国人：13.2％; p <0.001）。在最新出生的女孩中，按年龄划分的患病率比在早期出生的女孩中的患病率增长更快（p = 0.034）。每年的发病率为1.3％至2.4％。当我们将12-15岁的严重肥胖女孩与健康BMI进行比较时，平均体重在5年前已经很明显（16.5？kg与25.7？kg; p？<0.001），并且两组之间的BMI差异逐年增加。在7-10岁和11-14岁之间的LGCM显示，健康BMI组增加了3.32？kg / m 2，重度肥胖组增加了8.50？kg / m 2，相差2.6倍。结论由于高流行和长期流行趋势，青年发病的严重肥胖值得城市女孩特别关注。儿童晚期和青春期早期可能代表了预防和治疗的重要发展窗口，但为时已晚，无法完全预防青年发作的严重肥胖症。
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