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首页> 外文期刊>Journal of Clinical Medicine and Research >Relationship between blood pressure and arterial stiffness in patients undergoing antihypertensive treatment: A pilot study
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Relationship between blood pressure and arterial stiffness in patients undergoing antihypertensive treatment: A pilot study

机译：降压治疗患者血压与动脉僵硬度的关系：一项初步研究

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Mean arterial blood pressure is one of the principal modifiable factors which contribute to arterial stiffness. The influence of anti hypertensive drugs on arterial stiffness measured photoplethysmographically has not yet been studied. This pilot study was aimed at exploring the relationship between blood pressure (BP) and parameters of arterial stiffness on initiating antihypertensive treatment. Fourteen newly diagnosed hypertensive male or female patients aged 30 to 40 years participated in the study. The age, height, weight and body mass index was calculated for all patients. BP and arterial stiffness were measured once before treatment and weakly after initiation of treatment for 3 weeks. On comparing the pretreatment and post treatment weakly BP values, a highly significant decline in the systolic BP (p< 0.006) and mean BP (0.005) was observed, whereas diastolic BP showed a significant (0.016) decline. Post hoc analysis revealed that systolic BP (SBP) and diastolic BP (DBP) showed a significant decline (p = 0.011 and 0.027, respectively) at the second visit, which was around two weeks post treatment, while the mean BP showed a highly significant decrease (p = 0.009) at this time. However, pulse pressure and heart rate did not change significantly with treatment. Also, the parameters of arterial stiffness did not change significantly with treatment for the same duration. Thus, we concluded that reduction in BP in hypertensive patients as measured clinically by brachial cuff sphygmanometry seems to be dependent on the encounter interval. The decrease in blood pressure occured within three weeks, whereas changes in arterial stiffness do not occur even till three weeks of initiating the treatment.
机译：平均动脉血压是导致动脉僵硬的主要可调节因素之一。尚未研究抗高血压药物对光体积描记法测量的动脉僵硬度的影响。这项初步研究旨在探讨在开始降压治疗时血压（BP）和动脉僵硬参数之间的关系。十四名新诊断的30至40岁的高血压男性或女性患者参加了研究。计算所有患者的年龄，身高，体重和体重指数。在治疗前和治疗开始后的3周内分别测量BP和动脉刚度。通过比较治疗前后的微弱BP值，可观察到收缩压（p <0.006）和平均BP（0.005）显着下降，而舒张压BP显着（0.016）下降。事后分析显示，收缩压（SBP）和舒张压（DBP）在第二次就诊时（即治疗后约两周）显示出显着下降（分别为p = 0.011和0.027），而平均BP表现出高度显着性减少（p = 0.009）。但是，脉压和心率在治疗后没有明显改变。同样，在相同的治疗时间中，动脉僵硬度的参数也没有明显变化。因此，我们得出的结论是，通过腕袖血压计的临床测量，高血压患者的BP降低似乎取决于相遇的间隔。血压下降发生在三周之内，而动脉刚度的变化直到开始治疗的三周才发生。

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