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首页> 外文期刊>Journal of Clinical Medicine and Research >In vitro preventive effects of nitrate tolerance by a polyphenol-enriched extract of Hibiscus sabdariffa
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In vitro preventive effects of nitrate tolerance by a polyphenol-enriched extract of Hibiscus sabdariffa

机译：芙蓉多酚提取物对硝酸盐耐性的体外预防作用

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Treatment failure or tolerance, which rapidly leads to a reduced hemodynamic effects and therapeutic efficacy is the major limitation of long-term use of nitrates, including nitroglycerin (NTG) in the treatment of coronary artery disease. These effects are most often associated with oxidative stress. Thus, in this work, we were interested in the prevention of nitrate tolerance by the antioxidant compounds from?Hibiscus sabdariffa?L. crude extract, a plant from the Senegalese Pharmacopoeia, rich in polyphenols. Thoracic aorta segments without endothelium were taken from rats and incubated in isolated organ chambers. The vessels were then pre-exposed with the?H. sabdariffa?polyphenolic extract (HSE, 5.10-2?g/l) or antioxidants such as N-acetyl cysteine (NAC, 10-3?M) or vitamin C (VIT C, 10-2?M), taken as reference. After a 30 min treatment, aortic segments were exposed to NTG (50?μM, 1 h) to induce tolerance state before being contracted to adrenaline (10-8?to 10-5?M), and then relaxed with NTG (10-9?to 10-5?M). Polyphenols fromH. sabdariffa?potentiated the relaxant response to NTG, whatever the state of vascular?tolerance; the HSE partially corrected the?in vitro?nitrate tolerance. This work suggests interesting therapeutic perspectives by improving the response to treatment with nitrates in coronary patients.
机译：快速导致血液动力学效应降低的治疗失败或耐受性是长期使用硝酸盐（包括硝酸甘油（NTG））治疗冠状动脉疾病的主要限制。这些影响通常与氧化应激有关。因此，在这项工作中，我们对防止芙蓉芙蓉中的抗氧化剂对硝酸盐的耐受性感兴趣。粗提取物，一种来自塞内加尔药典的植物，富含多酚。不取内皮的胸主动脉节段取自大鼠，并在隔离的器官室中孵育。然后将容器预先暴露于？H。 sabdariffa？多酚提取物（HSE，5.10-2？g / l）或抗氧化剂，例如N-乙酰半胱氨酸（NAC，10-3？M）或维生素C（VIT C，10-2？M），作为参考。治疗30分钟后，将主动脉节段暴露于NTG（50？μM，1小时）以诱导耐受状态，然后收缩至肾上腺素（10-8？至10-5？M），然后用NTG（10- 9？至10-5？M）。 H的多酚无论血管耐受状态如何，sabdariffa？都能增强对NTG的松弛反应; HSE部分纠正了体外硝酸盐耐受性。这项工作通过改善冠心病患者对硝酸盐治疗的反应提出了有趣的治疗观点。

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