• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Clinical Medicine and Research >Comparative in vitro potency of four fluoroquinolones on clinical isolates over a year period
【24h】

Comparative in vitro potency of four fluoroquinolones on clinical isolates over a year period

机译：一年中四种氟喹诺酮类药物对临床分离株的体外体外药效比较

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

This study aimed at evaluating the efficacy of four common fluoroquinolone drugs over a year period on some clinical isolates. It also aimed at comparing statistically the average effects of each drug on the isolates. Five different clinical samples (urine, sputum, wound, blood and high vaginal swab [HVS]) from patients attending a university medical centre (between June 2011 and May 2012) were analysed for the purpose of bacteria isolation. The isolates were tested with commonly used flouroquinolones: pefloxacin (30 μg), ofloxacin (30 μg), sparfloxacin (10 μg), and ciprofloxacin (10 μg). Each sensitivity test was done in duplicate and a mean average of zone of inhibition was recorded. One hundred and eighty eight bacteria were isolated: Staphylococcus aureus (44.7%), Streptococcus pyogenes (6.4%), Escherichia coli (28.2%), Pseudomonas aeruginosa (8.5%), Klebsiella pneumonia (8.0%), and Proteus mirabilis (4.3%). All drugs were equally potent against the isolates, but a higher potency was seen in ofloxacin against P. mirabilis. The fluoroquinolones are a group of broad spectrum drugs effective in clinical cases. Their efficacy should be preserved by ensuring strict compliance to local drug policies.
机译：这项研究旨在评估一年中四种常见的氟喹诺酮药物对某些临床分离株的疗效。它还旨在统计比较每种药物对分离物的平均作用。为了分离细菌，对来自大学医疗中心（2011年6月至2012年5月）患者的五种不同临床样本（尿液，痰液，伤口，血液和高阴道拭子[HVS]）进行了分析。用常用的氟喹诺酮类药物对分离物进行测试：培氟沙星（30μg），氧氟沙星（30μg），司巴沙星（10μg）和环丙沙星（10μg）。重复进行每个敏感性测试，并记录抑制区域的平均平均值。分离出188个细菌：金黄色葡萄球菌（44.7％），化脓性链球菌（6.4％），大肠杆菌（28.2％），铜绿假单胞菌（8.5％），肺炎克雷伯菌（8.0％）和奇异变形杆菌（4.3％） ）。所有药物对分离物的效价均相同，但氧氟沙星对奇异假单胞菌的效价更高。氟喹诺酮类药物是在临床病例中有效的一组广谱药物。应确保严格遵守当地的药物政策，以保持其功效。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号