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首页> 外文期刊>Journal of Clinical Medicine Research >Hyaluronic Acid Fat Graft Myringoplasty Versus Autologous Platelet Rich Plasma
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Hyaluronic Acid Fat Graft Myringoplasty Versus Autologous Platelet Rich Plasma

机译：透明质酸脂肪移植物自体整形术与自体富血小板血浆

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Background: Hyaluronic acid fat graft myringoplasty (HAFGM) is an office-based technique for tympanic membrane perforation (TMP) treatment. It is simple, inexpensive, and performed under local anesthesia at the outpatient office department. We aimed to compare HAFGM technique to a recently described topical use of autologous platelet rich plasma myringoplasty (PRPM) in the repair of TMP. We also aimed to assess the hearing level improvement postoperatively.Methods: We conducted a prospective study in an adult tertiary care center between January 2015 and January 2016. Adult patients presenting with simple TMP were operated randomly using either HAFGM or PRPM under local anesthesia in an office-based setting. Perforations were classified into four grades. Success was considered when complete closure is achieved. Audiometric parameters were evaluated pre- and postoperatively.Results: We included 27 patients, of whom 16 were operated with HAFGM and 11 were operated with PRPM. Complete closure was achieved in 81.2% and 18.1%, respectively. Postoperatively, no worsening of bone conduction threshold was noted. The study was abandoned due to the low success rate in patients with PRPM. The pure tone audiometry was improved postoperatively in patients with closed tympanic membrane.Conclusions: The study was aborted because of the unsatisfactory obtained results using PRPM. It confirms once again the beneficial effect of hyaluronic acid in the healing process when added to fat graft myringoplasty. Furthermore, it requires no hospitalization.J Clin Med Res. 2017;9(1):30-34doi: https://doi.org/10.14740/jocmr2800w
机译：背景：透明质酸脂肪移植物干细胞移植术（HAFGM）是一种基于办公室的鼓膜穿孔（TMP）治疗技术。它简单，便宜，可在门诊部的局部麻醉下进行。我们旨在将HAFGM技术与最近描述的局部自体富血小板血浆干细胞移植术（PRPM）在TMP修复中的使用进行比较。方法：我们在2015年1月至2016年1月之间在成人三级护理中心进行了一项前瞻性研究。患有简单TMP的成年患者在局部麻醉下使用HAFGM或PRPM随机手术。基于办公室的设置。穿孔分为四个等级。当完全关闭实现时，将考虑成功。结果：我们纳入了27例患者，其中16例行HAFGM手术，11例行PRPM手术。完全封闭的比例分别为81.2％和18.1％。术后未发现骨传导阈值恶化。由于PRPM患者的成功率低，该研究被放弃。闭合性鼓膜患者术后纯音测听得到改善。结论：该研究因PRPM取得的结果不令人满意而中止。当将其加入脂肪移植物的移植后，再次证实了透明质酸在愈合过程中的有益作用。此外，它不需要住院。JClin Med Res。 2017; 9（1）：30-34doi：https://doi.org/10.14740/jocmr2800w

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