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首页> 外文期刊>Journal of Clinical Medicine Research >Visit-to-Visit Low-Density Lipoprotein Cholesterol Variability Is an Independent Determinant of Carotid Intima-Media Thickness in Patients With Type 2 Diabetes
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Visit-to-Visit Low-Density Lipoprotein Cholesterol Variability Is an Independent Determinant of Carotid Intima-Media Thickness in Patients With Type 2 Diabetes

机译：访视低密度脂蛋白胆固醇变异性是2型糖尿病患者颈动脉内膜中层厚度的独立决定因素。

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Background: Studies demonstrated that visit-to-visit variability in low-density lipoprotein cholesterol (LDLC) is an independent predictor of cardiovascular events in subjects with coronary artery disease. Whether visit-to-visit variability in LDLC levels affects subclinical atherosclerosis is unknown. This study sought to evaluate the role of visit-to-visit variability in LDLC levels on subclinical atherosclerosis.Methods: We evaluated 162 type 2 diabetic patients with measurement of carotid intima-media thickness (IMT). Intrapersonal mean and standard deviation (SD) of six measurements of LDLC during 12 months were calculated. Multivariate linear regressions assessed the independent correlates of carotid IMT.Results: The mean and SD of LDLC were 112 ± 22 and 15 ± 10 mg/dL, respectively, and 43.2% of patients were on hypolipidemic drugs. Age (standardized β = 0.355, P < 0.001), male sex (standardized β = 0.234, P = 0.002) and SD-LDLC (standardized β = 0.201, P = 0.009) emerged as independent determinants of carotid maximum IMT independently of mean LDLC levels, body mass index (BMI), waist circumference, duration and treatment of diabetes, means and SDs of glycemic and other lipid variables, and uses of hypolipidemic and anti-hypertensive medications (R2 = 0.15). Results did not change when mean IMT was used instead of maximum IMT. After controlling for age and sex, maximum IMT was thicker in patients with the highest compared to those with other three quartiles of SD-LDLC combined (1.14 ± 0.04 (SE) vs. 1.01 ± 0.02 mm, P = 0.01). Independent determinants of SD-LDLC were mean LDLC, use of hypolipidemic drugs, fasting triglyceride and visit-to-visit variability in HbA1c.Conclusions: Consistency of LDLC levels may be important to subclinical atherosclerosis in real-world patients with type 2 diabetes. It may be important for patients on lipid-lowering drugs to prevent non-compliance.J Clin Med Res. 2017;9(4):310-316doi: https://doi.org/10.14740/jocmr2871w
机译：背景：研究表明，低密度脂蛋白胆固醇（LDLC）的访视变异性是冠心病患者心血管事件的独立预测因子。 LDLC水平的访视变异是否影响亚临床动脉粥样硬化尚不清楚。这项研究旨在评估来访变异性在LDLC水平对亚临床动脉粥样硬化的作用。方法：我们评估了162位2型糖尿病患者的颈动脉内中膜厚度（IMT）。计算了12个月内六次LDLC的人际平均数和标准差（SD）。结果：LDLC的平均值和SD分别为112±22和15±10 mg / dL，并且43.2％的患者接受降血脂药物治疗。年龄（标准β= 0.355，P <0.001），男性（标准β= 0.234，P = 0.002）和SD-LDLC（标准β= 0.201，P = 0.009）是颈动脉最大IMT的独立决定因素，与平均LDLC无关水平，体重指数（BMI），腰围，糖尿病的持续时间和治疗方法，血糖和其他脂质变量的平均值和标准差以及降血脂药和抗高血压药的使用（R2 = 0.15）。当使用平均IMT代替最大IMT时，结果没有改变。在控制了年龄和性别之后，与其他三个四分位数的SD-LDLC合并者相比，最高者的最大IMT较厚（1.14±0.04（SE）对1.01±0.02 mm，P = 0.01）。 SD-LDLC的独立决定因素是平均LDLC，降血脂药的使用，空腹甘油三酯和HbA1c的就诊变异性。对于使用降脂药的患者，防止其不遵守可能很重要。JClin Med Res。 2017; 9（4）：310-316doi：https://doi.org/10.14740/jocmr2871w

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