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首页> 外文期刊>Journal of Clinical Medicine Research >Histology of the Oral Mucosa in Patients With BRONJ at III Stage: A Microscopic Study Proves the Unsuitability of Local Mucosal Flaps
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Histology of the Oral Mucosa in Patients With BRONJ at III Stage: A Microscopic Study Proves the Unsuitability of Local Mucosal Flaps

机译：BRONJ患者III期口腔黏膜的组织学：显微镜研究证明局部黏膜皮瓣不适合

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Background: Bisphosphonate Osteonecrosis of the Jaw (BRONJ) is a newly recognized condition reported in patients treated with aminobisphosphonates (BF). BRONJ is defined as the presence of exposed necrotic alveolar bone that does not resolve over a period of 8 weeks in a patient taking bisphosphonates who has not had radiotherapy to the jaw. Treatment protocols have been outlined, but trials and outcomes of treatment and long-term follow-up data are not yet available. In 2004 an expert panel outlined recommendations for the management of bisphosphonate-associated osteonecrosis of the jaws. Through the histological study of the oral mucosa over the bone necrosis and around the osteonecrosis area in 8 patients affected by BRONJ at III stage, the authors highlight the inappropriateness of the local mucosal flaps to cover the losses of substance of the jaw, BF-related.Methods: Mucosa tissue was taken from 8 patients, affected by BRONJ, III stage. The samples taken from the mucosa around and over the osteonecrosis area were fixed with formalin and an ematossilina-eosin dichromatic coloring was carried out.Results: The samples of mucosa showed pathognomonic signs of cell suffering that prove that in these patients using local mucosa flaps is inappropriate.Conclusions: The authors suggest that only a well vascularized flap as free flap must be used to cover the osteonecrosis area in patients with BRONJ stage III. Because of the structural instability of the mucosa in patients suffering of osteonecrosis Bf related the local flaps are prone to ulceration and to relapse.doi: http://dx.doi.org/10.4021/jocmr1253e
机译：背景：双膦酸盐下颌骨坏死（BRONJ）是氨基双膦酸盐（BF）治疗患者中新发现的一种疾病。 BRONJ被定义为存在暴露的坏死牙槽骨，该牙槽骨在接受双膦酸盐治疗且未经过颌骨放疗的患者中，在8周内仍未消退。已经概述了治疗方案，但是尚无治疗的试验和结果以及长期随访数据。 2004年，一个专家小组概述了双膦酸盐相关颌骨坏死的治疗建议。通过对8例BRONJⅢ期患者的骨坏死及周围骨坏死区域周围口腔黏膜的组织学研究，作者强调了局部黏膜瓣不适合掩盖与BF相关的颌骨物质损失方法：取8例BRONJ III期患者的黏膜组织。用福尔马林固定从骨坏死区域周围和上方的粘膜取来的样本，并进行ematossilina-eosin双色染色。结论：作者建议，只有BRONJ III期患者必须使用血管良好的皮瓣作为游离皮瓣覆盖骨坏死区域。由于骨坏死Bf相关患者粘膜的结构不稳定性，局部皮瓣容易溃疡和复发.doi：http://dx.doi.org/10.4021/jocmr1253e

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