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首页> 外文期刊>Journal of Clinical Medicine Research >A Single Dose of Amoxicillin and Dexamethasone for Prevention of Postoperative Complications in Third Molar Surgery: A Randomized, Double-Blind, Placebo Controlled Clinical Trial
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A Single Dose of Amoxicillin and Dexamethasone for Prevention of Postoperative Complications in Third Molar Surgery: A Randomized, Double-Blind, Placebo Controlled Clinical Trial

机译：单剂量阿莫西林和地塞米松预防第三次磨牙手术术后并发症的发生：一项随机，双盲，安慰剂对照的临床试验

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Background: The aim of this study was to assess the efficacy of a single prophylactic dose of amoxicillin and/or dexamethasone in preventing postoperative complications (PC) after a surgical removal of a single mandibular third molar (M3).?Methods: This study is a randomized, placebo controlled clinical trial. Four groups were included: Group 1 (G1) included a prophylactic dose of 2 g of amoxicillin and 8 mg of dexamethasone; Group 2 (G2) included a prophylactic dose of 2 g of amoxicillin and 8 mg of placebo; Group 3 (G3) included a prophylactic dose of 8 mg of dexamethasone and 2 g of placebo and; Group 4 (G4) placebo.?Results: Fifty patients were included. It was observed one case of alveolar infection (2%) and two of alveolar osteitis (4%) resulting in three PC (6%). No statistical differences were observed between therapeutic groups for development of PC, trismus, pain and edema. The use of antibiotics showed an absolute risk reduction (ARR) for PC development of 3.52% and the number needed to treat (NNT) was 29.?Conclusion: Prophylactic antibiotics and corticoid in a single dose regimen did not bring any benefit on M3 surgeries.doi: http://dx.doi.org/10.4021/jocmr1160w
机译：背景：本研究的目的是评估单次预防剂量的阿莫西林和/或地塞米松在通过手术切除单个下颌第三磨牙（M3）后预防术后并发症（PC）的功效。方法：本研究是一项随机，安慰剂对照的临床试验。包括四组：第一组（G1）包括预防剂量的2 g阿莫西林和8 mg地塞米松;第2组（G2）的预防剂量为2克阿莫西林和8毫克安慰剂;第3组（G3）的预防剂量为8 mg地塞米松和2 g安慰剂，第4组（G4）安慰剂。结果：纳入50例患者。观察到1例肺泡感染（2％）和2例肺泡性骨炎（4％）导致3例PC（6％）。治疗组之间PC，三头肌，疼痛和水肿的发生没有统计学差异。抗生素的使用显示PC发育的绝对风险降低（ARR）为3.52％，需要治疗的数量（NNT）为29。结论：单一剂量的预防性抗生素和皮质类固醇激素对M3手术没有任何益处。 .doi：http：//dx.doi.org/10.4021/jocmr1160w

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