Isolated Adrenocorticotropic Hormone Deficiency and Severe Hypercalcemia After Destructive Thyroiditis in a Patient on Nivolumab Therapy With a Malignant Melanoma

Kohzo Takebayashi; Atsushi Ujiie; Mio Kubo; Sho Furukawa; Mototaka Yamauchi; Hiroyuki Shinozaki; Tatsuhiko Suzuki; Rika Naruse; Kenji Hara; Takafumi Tsuchiya; Toshihiko Inukai

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Isolated Adrenocorticotropic Hormone Deficiency and Severe Hypercalcemia After Destructive Thyroiditis in a Patient on Nivolumab Therapy With a Malignant Melanoma

机译：患有恶性黑色素瘤的Nivolumab治疗的患者中的破坏性甲状腺炎后，孤立的促肾上腺皮质激素缺乏和严重的高钙血症

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We describe a 58-year-old man with a malignant melanoma metastasis to the liver. After initiation of nivolumab therapy, he developed destructive thyroiditis and subsequently simultaneous isolated adrenocorticotropic hormone (ACTH) deficiency and severe hypercalcemia. Although isolated ACTH deficiency and hypercalcemia due to nivolumab therapy are both rare occurrences, these conditions can often cause a severe clinical course accompanied by a disturbance of consciousness. Therefore, clinicians should pay attention to these possible side effects of nivolumab if the patients have clinical symptoms, such as fatigue and a disturbance of consciousness.J Clin Med Res. 2018;10(4):358-362doi: https://doi.org/10.14740/jocmr3257w.

机译：我们描述了一个58岁的恶性黑色素瘤转移到肝脏的男人。在开始使用纳武单抗治疗后，他患上了破坏性甲状腺炎，随后同时分离出促肾上腺皮质激素（ACTH）缺乏症和严重的高钙血症。尽管因纳武单抗引起的孤立ACTH缺乏症和高钙血症很少见，但这些情况通常会导致严重的临床过程，并伴有意识障碍。因此，如果患者有临床症状，例如疲劳和意识障碍，临床医生应注意nivolumab的这些可能的副作用。 2018; 10（4）：358-362doi：https://doi.org/10.14740/jocmr3257w。

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《Journal of Clinical Medicine Research》 |2018年第4期|共5页
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Kohzo Takebayashi; Atsushi Ujiie; Mio Kubo; Sho Furukawa; Mototaka Yamauchi; Hiroyuki Shinozaki; Tatsuhiko Suzuki; Rika Naruse; Kenji Hara; Takafumi Tsuchiya; Toshihiko Inukai;
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中图分类临床医学;
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1. Isolated adrenocorticotropic hormone deficiency and thyroiditis associated with nivolumab therapy in a patient with advanced lung adenocarcinoma: a case report and review of the?literature [J] . Nobumasa Ohara, Michi Kobayashi, Kazumasa Ohashi, Journal of Medical Case Reports . 2019,第1期

机译：晚期肺腺癌患者中独立的促肾上腺皮质激素缺乏和甲状腺炎伴nivolumab治疗：一例病例并文献复习
2. Isolated adrenocorticotropic hormone deficiency possibly caused by nivolumab in a metastatic melanoma patient [J] . Fujimura Taku, Kambayashi Yumi, Furudate Sadanori, The Journal of dermatology . 2017,第3期

机译：孤立的肾上腺皮质激素缺乏症可能由Nivolumab造成的转移性黑色素瘤患者引起
3. Isolated adrenocorticotropic hormone deficiency associated with nivolumab therapy [J] . Narahira Atsushi, Yanagi Teruki, Cho Kyu Yong, The Journal of dermatology . 2017,第4期

机译：孤立的肾上腺皮质激素激素缺乏患者与水肺疗法相关
4. Isolated Growth Hormone Deficiency Type 2: From Gene to Therapy [C] . Maria Consolata Miletta, Didier Lochmatter, Vibor Pektovic, European Society of Pediatric Endocrinology Advanced Seminar in Developmental Endocrinology . 2012

机译：分离的生长激素缺乏型2：从基因到治疗
5. Patients With Antithyroid Antibodies Are Prone To Develop Destructive Thyroiditis by Nivolumab: A Prospective Study [D] . Kobayashi Tomoko, 小林朋子 2019

机译：抗甲状腺抗体的患者通过Nivolumab容易发展为破坏性甲状腺炎：一项前瞻性研究
6. Isolated Adrenocorticotropic Hormone Deficiency and Severe Hypercalcemia After Destructive Thyroiditis in a Patient on Nivolumab Therapy With a Malignant Melanoma [O] . Kohzo Takebayashi, Atsushi Ujiie, Mio Kubo, 2018

机译：患有恶性黑色素瘤的Nivolumab治疗的患者在破坏性甲状腺炎后的单独促肾上腺皮质激素缺乏和严重高钙血症
7. Isolated Adrenocorticotropic Hormone Deficiency Caused by Nivolumab in a Patient with Metastatic Lung Cancer [O] . Kazuhiko Takaya, Miwa Sonoda, Ayako Fuchigami, 2017

机译：孤立的肾上腺皮质激素缺乏症由患有转移性肺癌的患者患者引起的血管缺乏症

Isolated Adrenocorticotropic Hormone Deficiency and Severe Hypercalcemia After Destructive Thyroiditis in a Patient on Nivolumab Therapy With a Malignant Melanoma

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