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首页> 外文期刊>Journal of Clinical Neurology >Cardiac Troponin T Elevation After Stroke: Relationships Between Elevated Serum Troponin T, Stroke Location, and Prognosis
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Cardiac Troponin T Elevation After Stroke: Relationships Between Elevated Serum Troponin T, Stroke Location, and Prognosis

机译：卒中后心脏肌钙蛋白T升高：血清肌钙蛋白T升高，卒中位置与预后之间的关系

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Background and Purpose Elevation of serum cardiac troponin T (cTnT) is regarded as a specific marker of acute coronary syndrome. Serum cTnT can be increased in patients with acute ischemic stroke, but its clinical implications remain unclear. The aim of this study was to identify the relationships between elevated cTnT and stroke severity, location, and prognosis. Methods From January 2005 to December 2006, this study recruited 455 consecutive patients who were admitted to Kangbuk Samsung Hospital due to acute ischemic stroke within 3 days of onset, which was confirmed by diffusion magnetic resonance imaging. A total of 416 patients was finally included and divided into 2 groups: an elevated cTnT group ( n =45) and a normal cTnT group ( n =371). The short-term prognosis was assessed by 30-day modified Rankin Scale responder analysis was compared between the two groups. Results Serum cTnT was elevated in 10.8% of cases, with elevated cTnT associated with greater stroke severity, as assessed by the National Institutes of Health Stroke Scale score, Insular-lobe involvement was more common in patients with elevated cTnT than in the normal cTnT group. Short-term prognosis was more unfavorable in the elevated cTnT group than in the normal cTnT group. Multivariate regression analysis indicated that elevated cTnT was independently related to insular involvement, cardioembolism, and unfavorable outcome. Conclusions Elevated cTnT in acute ischemic stroke was associated with severe neurological deficits at stroke onset and damages to the insular lobe. The outcome of acute ischemic stroke was worse for patients with elevated cTnT than for those with normal cTnT. The pathomechanism underlying acute ischemic stroke and subclinical myocardial damage warrants further study.
机译：背景与目的血清心肌肌钙蛋白T（cTnT）升高被认为是急性冠状动脉综合征的特异性标志物。急性缺血性中风患者的血清cTnT可以升高，但其临床意义尚不清楚。这项研究的目的是确定cTnT升高与卒中严重程度，位置和预后之间的关系。方法2005年1月至2006年12月，本研究招募了455例连续3天内因急性缺血性卒中而入院至北北三星医院的患者，这经扩散核磁共振成像证实。最终总共纳入416例患者，分为2组：cTnT组升高（n = 45）和cTnT正常组（n = 371）。短期预后通过30天改良Rankin Scale应答者分析进行评估，并在两组之间进行比较。结果，根据美国国立卫生研究院卒中量表评分评估，血清cTnT升高了10.8％，cTnT升高与卒中严重程度相关，cTnT升高的患者比正常cTnT组更常见岛叶。升高的cTnT组的短期预后比正常的cTnT组更不利。多元回归分析表明，cTnT升高与岛突受累，心脏栓塞和不良预后独立相关。结论急性缺血性中风中cTnT升高与中风发作时严重的神经功能缺损和岛叶损伤有关。 cTnT升高的患者急性缺血性卒中的结果比cTnT正常的患者更差。急性缺血性卒中和亚临床心肌损伤的病理机制值得进一步研究。

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