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首页> 外文期刊>Journal of Clinical and Experimental Investigations >Evaluation of efficacy, safety and antioxidant effect of Nigella sativa in patients with psoriasis: A randomized clinical trial
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Evaluation of efficacy, safety and antioxidant effect of Nigella sativa in patients with psoriasis: A randomized clinical trial

机译：评估Nigella sativa对牛皮癣患者的疗效，安全性和抗氧化作用：一项随机临床试验

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Objective: Various drugs are used for treatment of psoriasis such as retinoids, hydroxyurea, methotrexate, and infliximab with variable benefits, but these drugs are associated with side effects. The aim of this study was to evaluate efficacy, safety of topical and oral doses of Nigella sativa (NS) in psoriatic patients.Methods: sixty patients with mild to moderate plaque and palmoplanter psoriasis were recruited for the study from January 2010 to March 2011. The patients were randomly divided into three groups: Twenty patients (group 1) were treated with (10% w/w) ointment of (NS), group 2 (20 patients) treated with crude powder of (NS), 500mg capsule t.d.s; group 3 (20 patients) were treated with the combination of ointment and capsule of (NS).PASI score was used for clinical evaluation of effect, and serum malondialdehyde (MDA) as an indicator of oxidative status.Results: (NS) ointment achieved complete cure of psoriatic lesions, excellent and good response in 65% of patients, with a relapse rate of 31% four weeks after cessation of treatment. Oral doses of (NS) produced good response in 50% of patients, with a relapse rate of 50% noticed four weeks after treatment cessation. The combination of (NS) ointment and oral doses achieved complete cure of lesions, excellent and good responses in 85% of patients, with a relapse rate of 18%. (NS) was well tolerated, no side effects were observed.Conclusion: (NS) has anti psoriatic effect with the best effect obtained with the combination of ointment and the oral dosage form of (NS).
机译：目的：用于治疗牛皮癣的各种药物（如类维生素A，羟基脲，甲氨蝶呤和英夫利昔单抗）具有不同的获益，但这些药物具有副作用。这项研究的目的是评估银屑病患者局部和口服Nigella sativa（NS）的疗效，安全性。方法：从2010年1月至2011年3月，招募了60例轻度至中度斑块和掌plant银屑病患者。将患者随机分为三组：20例（1组）用（10％w / w）软膏（NS）治疗;第二组（20例）用（NS）粗粉治疗; 500mg胶囊剂量;第3组（20例）采用软膏加（NS）胶囊联合治疗，PASI评分用于临床疗效评价，血清丙二醛（MDA）作为氧化状态的指标。完全治愈银屑病皮损，在65％的患者中有出色和良好的反应，停止治疗后4周的复发率为31％。口服（NS）剂量可在50％的患者中产生良好的反应，停药后四周可观察到50％的复发率。 （NS）软膏和口服剂量的结合可以完全治愈病灶，在85％的患者中实现出色和良好的反应，复发率为18％。结论：（NS）具有抗银屑病的作用，以软膏和（NS）的口服剂型联合使用可获得最佳效果。

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