...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Clinical and Experimental Investigations >Relationship between adiponectin and adiponectin receptor 1 gene polymorphisms with colorectal cancer
【24h】

Relationship between adiponectin and adiponectin receptor 1 gene polymorphisms with colorectal cancer

机译：脂联素和脂联素受体1基因多态性与大肠癌的关系

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Objectives: Adiponectin is a protein synthesized from adipose tissue and it is also an endogeneous insulin sensitizer. Adiponectin seems to act in preneoplastic colonic lesions to regulate cell growth by activating, altering, or interacting with several pathways including the leptin and the NFkB pathways. This study aims to investigate the relationship of T/G rs2241766ADIPOQ exon 2 (+45,codon 15) and A/G rs2275738ADIPOR1 intron 1 (-106) polymorphisms with CRC risk. Methods: The studying group consist of total 266 person which 129 of them are colorectal cancer cases who were diagnosed at the Mersin University Medical Faculty Hospital and 137 controls participating. Genotypes were determined using PCR/RFLP methods. Results: It was found that there is no relationship between T/G rs2241766ADIPOQ exon 2 (+45, codon 15) and A/G rs2275738ADIPOR1 intron 1 (-106) polymorphisms and the risk of developing colorectal cancer. It was determined an increasing risk of colorectal cancer with male subjects and old age groups. Conclusion: In conclusion, it was found that rs2241766 and rs2275738 polymorphisms may not be related to the progression of colorectal cancer.
机译：目的：脂联素是一种从脂肪组织合成的蛋白质，也是一种内源性胰岛素增敏剂。脂联素似乎在肿瘤前结肠损伤中起作用，通过激活，改变或与瘦素和NFkB途径等多种途径相互作用来调节细胞生长。这项研究旨在调查T / G rs2241766ADIPOQ外显子2（+45，密码子15）和A / G rs2275738ADIPOR1内含子1（-106）多态性与CRC风险的关系。方法：研究组共266人，其中在梅尔辛大学医学院附属医院诊断为大肠癌的129例，参加对照组的137例。使用PCR / RFLP方法确定基因型。结果：发现T / G rs2241766ADIPOQ外显子2（+45，密码子15）和A / G rs2275738ADIPOR1内含子1（-106）多态性与患结直肠癌的风险之间没有关系。已确定男性受试者和老年组患结直肠癌的风险增加。结论：总之，发现rs2241766和rs2275738的多态性可能与大肠癌的进展无关。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号