Objective: Erythrocyte Sedimentation Rate (ESR) can be used for the follow-up of number of diseases. In recent years, closed automated systems that measure ESR directly from a capped EDTA and citrate blood sample tube have been developed. In this study, we aimed to compare and evaluate the consistence of assay results of iSed Alcor Auto-instrument and Berkhun SDM60 Auto-instrument. Methods: K2EDTA and citrated blood samples were taken from 149 randomly selected outpatients. The ESR of blood samples in tubes containing K2EDTA was determined by iSed Alcor Auto-instrument whereas Berkhun SDM60 Auto-instrument was used to determine the ESR of blood samples in tubes containing citrate. Results: The mean ± SD ESR was 24.48 ± 23.10 mm/hr (95% CI for the mean was 20.54–28.02 mm/hr) for iSed Alcor Auto-instrument and 23.94 ± 17.24 mm/hr (95% CI for the mean was 21.15–26.73 mm/hr) for the Berkhun Auto-instrument. We found the mean difference between two methods as 0.336 mm/hr (95% CI for the mean was ?2.06 to 1.39 mm/hr; P = 0.701). The obtained correlation coefficient was 0.90 (P = 0.0001). There was no evidence of systemic bias, equal to 0.3 mm/hr (limits of agreement, –20.6 to 21.2 mm/hr). Conclusion: iSed Alcor Auto-instrument and Berkhun SDM60 Auto-instrument might be used as alternative systems each other. However, it should be monitored carefully in especially high ESR (>50 mm/hr) results and the results should be checked according to the Westergren method.
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机译：目的：红细胞沉降率（ESR）可用于多种疾病的随访。近年来，已经开发出了直接从带盖的EDTA和柠檬酸盐血样管中直接测量ESR的封闭式自动化系统。在这项研究中，我们旨在比较和评估iSed Alcor自动仪器和Berkhun SDM60自动仪器的测定结果的一致性。方法：从149名随机选择的门诊患者中采集K2EDTA和柠檬酸血样。装有K2EDTA的试管中血样的ESR通过iSed Alcor自动仪器测定，而Berkhun SDM60自动仪器用于测定含柠檬酸盐试管中的血样ESR。结果：iSed Alcor自动仪器的平均±SD ESR为24.48±23.10 mm / hr（95％CI为20.54–28.02 mm / hr）和23.94±17.24 mm / hr（95％CI为Berkhun自动仪器的21.15–26.73 mm / hr）。我们发现两种方法之间的均值差为0.336 mm / hr（均值的95％CI为2.06至1.39 mm / hr; P = 0.701）。获得的相关系数为0.90（P = 0.0001）。没有证据表明系统性偏倚等于0.3 mm / hr（一致极限，–20.6至21.2 mm / hr）。结论：iSed Alcor自动仪器和Berkhun SDM60自动仪器可以相互替代使用。但是，应仔细监测其ESR（> 50 mm / hr）特别高的结果，并应根据Westergren方法检查结果。
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