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首页> 外文期刊>Journal of Clinical and Experimental Investigations >The relationship between serum uric acid level and concentration of proangiogenic mononuclear progenitor cells in patients with chronic heart failure
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The relationship between serum uric acid level and concentration of proangiogenic mononuclear progenitor cells in patients with chronic heart failure

机译：慢性心力衰竭患者血清尿酸水平与促血管生成单个核祖细胞浓度的关系

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Objective: Serum uric acid (UA) is considered as a marker of natural progression of chronic heart failure (CHF). Progression of CHF associates with declining of circulating mononuclear progenitor cells (MPCs) in the blood. The objective of this study was to evaluate the interrelationship between SUA concentrations and proangiogenic MPCs in ischemic CHF patients. Methods: The study was structured retrospectively after determining the coronary artery disease (CAD) by contrast-enhanced spiral computed tomography angiography in 126 subjects (54 male), aged 48 to 62 years, with CHF. Serum UA level was measured by enzymatic method and N-terminal proBNP (NT-pro-BNP) level was examined by immunoelectrochemiluminesence method. All biomarkers were measured at baseline. Results: Concentrations of SUA were distributed by quartiles (Me; IQR): QI=20.11 (19.06; 22.33) mmol/l; QII=27.53 (23.2; 31.10) mmol/l; QIII=35.80 (32.0; 39.0) mmol/l; and QIV=44.9 (40.00; 49.60) mmol/l. Cox proportional adjusted Odds Ratios analyses for CD14+CD309+ and CD14+CD309+Tie2+ MPCs by SUA Quartiles (Q) has showed that high Q (Q3 and Q4) of SUA versus low Q (Q1 and Q2) associated with increased risk of depletion of both CD14+CD309+ and CD14+CD309+Tie2+ MPCs. The ROC analysis has been showed that there was the cut-off point for the SUA level with the best prognostic potential on the risk of decreasing MPCs in both models equal 31.5 mmol/l. Conclusion: Circulated level of proangiogenic MPCs is declined progressively depended on quartiles of serum UA level in CHF subjects. We suggest that mild elevation of serum UA might be considered as a predictor of low proangiogenic MPCs in CHF patients.
机译：目的：血清尿酸（UA）被认为是慢性心力衰竭（CHF）自然进展的标志。 CHF的进展与血液中循环单核祖细胞（MPC）下降有关。这项研究的目的是评估缺血性CHF患者的SUA浓度与促血管生成MPC之间的相互关系。方法：本研究采用回顾性增强螺旋计算机断层扫描血管造影术确定了冠心病的126名受试者（54名男性）中的冠状动脉疾病（CAD），并进行了回顾性研究。酶法测定血清UA水平，免疫电化学法测定N端proBNP（NT-pro-BNP）水平。在基线测量所有生物标志物。结果：SUA浓度按四分位数（Me; IQR）分配：QI = 20.11（19.06; 22.33）mmol / l; QII = 27.53（23.2; 31.10）mmol / l; QIII = 35.80（32.0; 39.0）mmol / l; QIV ＝ 44.9（40.00; 49.60）mmol / l。 SUA四分位数（Q）对CD14 + CD309 +和CD14 + CD309 + Tie2 + MPC进行Cox比例调整的赔率比分析表明，SUA的高Q（Q3和Q4）与低Q（Q1和Q2）相关，且消耗的风险增加CD14 + CD309 +和CD14 + CD309 + Tie2 + MPC。 ROC分析显示，在两个模型中，SUA水平的临界点对MPC降低的风险具有最佳的预后潜力，等于31.5 mmol / l。结论：CHF受试者血清UA水平的四分位数逐渐降低了促血管生成MPC的循环水平。我们建议，血清UA的轻度升高可能被认为是CHF患者低促血管生成MPC的预测指标。

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