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首页> 外文期刊>Journal of Clinical and Experimental Investigations >Fibrin sealant as a carrier for sustained delivery of antibiotics
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Fibrin sealant as a carrier for sustained delivery of antibiotics

机译：纤维蛋白密封剂作为持续递送抗生素的载体

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Objective: To evaluate the activity and sustained release of antibiotics from fibrin sealant against common strains of ocular bacteria.Methods: Vancomycin, ceftazidime, moxifloxacin and lomefloxacin were incorporated into fibrin sealant in the shape of discs. Each antibiotic disc and control fibrin disc without drug was tested in vitro against standard bacterial strains of Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pneumoniae and Pseudomonas aeroginosa. After 24 hours of incubation at 37 °C, the discs were transferred to new plates of bacteria and triplicated for each antibiotic.Results: All antibiotic discs demonstrated detectable activity after 24 hours. Vancomycin had the longest duration of activity (4 days) on the S. pneumonia grown plate. The moxifloxacin discs showed a prolonged inhibition of S. aureus and S. pneumonia for 3 days and inhibited the other strains for 2 days.Conclusion: Fibrin sealants provided prolonged drug delivery, which indicates that antibiotic-loaded fibrin clots could be useful for early ocular postoperative care and treatment
机译：目的：评价纤维蛋白封闭剂对常见眼细菌的抗菌活性和持续释放。方法：将万古霉素，头孢他啶，莫西沙星和洛美沙星以圆盘状掺入纤维蛋白封闭剂中。每个无药的抗生素光盘和对照纤维蛋白光盘均在体外针对金黄色葡萄球菌，表皮葡萄球菌，肺炎链球菌和铜绿假单胞菌的标准细菌菌株进行了测试。在37°C下孵育24小时后，将圆盘转移到新的细菌平板上，并对每种抗生素进行一式三份。结果：所有抗生素圆盘在24小时后均显示出可检测的活性。万古霉素在肺炎链球菌生长平板上的活动时间最长（4天）。莫西沙星圆片对金黄色葡萄球菌和肺炎链球菌的抑制作用延长了3天，而对其他菌株的抑制作用则为2天。结论：纤维蛋白封闭剂可延长药物输送时间，这表明载有抗生素的纤维蛋白凝块可用于早期眼术后护理与治疗

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