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首页> 外文期刊>Journal of Clinical Sciences >Two component preparation of fibrin glue and its clinical evaluation in split skin grafting
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Two component preparation of fibrin glue and its clinical evaluation in split skin grafting

机译：纤维蛋白胶的二组分制备及其在劈裂皮肤移植中的临床评价

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Background: Fibrin glue is an alternative to conventional suturing and stapling of skin grafts and has several advantages. It acts as a sealant and a hemostatic agent with an added adhesive property that has been reportedly used in many specialties with better outcomes. Objective: The objective was to study the effectiveness of fibrin glue in anchoring the split skin graft to the wound bed and to analyze the advantages, disadvantages, and outcome of using fibrin glue compared to suturing and stapling. Methodology: A total of 60 patients undergoing split skin grafting for various indications were studied. Each patient was used as both case and control, where fibrin glue was applied on one half and sutures and/or staples were applied on the other half of the same ulcer. Examination of the wound was conducted by two observers independently from the 3suprd/sup postoperative day at regular intervals onward and included inspection for the graft uptake, soakage, and infection and graded accordingly based on the three parameters. Results: Overall, graft uptake was better in fibrin glue study group. Furthermore, soakage and infection were less in fibrin glue study group when compared to the conventional suturing/stapling. No difference in infections rate was found among burns and postsurgical raw area patients. Conclusion: The use of fibrin glue is a simple, safe, and cost-effective method, with a rapid technique to fix the skin graft, avoid peroperative bleeding and postoperative collection, better uptake of graft, and better overall results.
机译：背景：纤维蛋白胶是传统缝合和缝合皮肤移植物的替代方法，具有许多优点。据报道，它可作为密封剂和止血剂，具有附加的粘合性能，据报道已在许多专业领域使用，效果更好。目的：研究纤维蛋白胶在将裂开的皮肤移植物锚固到伤口床上的有效性，并分析与缝合和缝合相比，使用纤维蛋白胶的优缺点和结果。方法：共研究了60例因各种适应症而行皮肤劈开术的患者。每例患者均作为病例和对照，其中在同一溃疡的另一半上涂上纤维蛋白胶，在另一半上涂上缝线和/或钉书钉。由两名观察员在术后第3天独立地定期检查伤口，并定期检查移植物的吸收，浸透和感染情况，并根据这三个参数进行相应分级。结果：总体而言，纤维蛋白胶研究组的移植物吸收更好。此外，与传统的缝合/缝合相比，纤维蛋白胶研究组的浸泡和感染较少。烧伤和手术后生区患者的感染率没有差异。结论：使用纤维蛋白胶是一种简单，安全且具有成本效益的方法，它具有快速的技术来固定皮肤移植物，避免了术中出血和术后收集，更好地吸收了移植物，并获得了更好的整体效果。

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