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首页> 外文期刊>Journal of Clinical Sciences >A comparison of propofol - fentanyl with midazolam – pentazocine combination for sedation and analgesia during colonoscopy in Ibadan Nigeria
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A comparison of propofol - fentanyl with midazolam – pentazocine combination for sedation and analgesia during colonoscopy in Ibadan Nigeria

机译：尼日利亚伊巴丹市结肠镜检查期间丙泊酚-芬太尼与咪达唑仑-喷他佐辛合用镇静镇痛的比较

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Background: Benzodiazepines, narcotics, and propofol in different combinations are administered to provide sedation and analgesia during colonoscopy. The study aimed to compare the efficacy and safety of midazolam-pentazocine with the propofol-fentanyl combination for sedation and analgesia during colonoscopy. Patients and Methods: This prospective randomized, double-blind study was conducted in 62 adults aged 18–82 years scheduled for colonoscopy. Patients were assigned into two groups, Group A (n = 31) received midazolam 2.5–5.0 mg with pentazocine 15–30 mg, whereas Group B (n = 31) received propofol 0.5 mg/kg with fentanyl 0.5ug/kg before the procedure. Efficacy was measured by the depth of sedation using Ramsay sedation score (RSS), pain score, and recovery from sedation, whereas safety was evaluated with heart rate, blood pressure (BP), and oxygen saturation. Results: There was no statistically significant difference between the two groups with respect to demographic and clinical data. The patients in Group B were more sedated with a mean RSS of 4.1 ± 0.79 compared with 2.07 ± 0.74 in Group A (P = 0.001). The mean pain score during the procedure was lower in Group B 3.19 ± 1.9 compared with 4.8 ± 1.9 in Group A (P = 0.001). The recovery time was faster in Group B compared with Group A, 24 versus 46 min, respectively (P = 0.001). The systolic BP at 5 and 10 min was lower in Group B (P = 0.024 and P = 0.001), respectively, as well as the diastolic BP at 5 and 10 min (P = 0.042 and P = 0.04), respectively. Hypotension was observed in six patients in Group B compared to two patients in Group A. There was no difference in the heart rates in both groups. Two patients in both groups had desaturation 90%, and oxygen was administered to maintain the oxygenation. No patient developed apnea that would have warranted endotracheal intubation. Conclusion: Propofol-fentanyl combination provided better sedation, less painful procedure, and shorter recovery time with minimal cardiorespiratory complication.
机译：背景：苯二氮卓类药物，麻醉剂和丙泊酚以不同的组合给药，以在结肠镜检查期间提供镇静和镇痛作用。该研究旨在比较咪达唑仑-喷他佐辛与丙泊酚-芬太尼组合在结肠镜检查期间的镇静和镇痛效果和安全性。患者和方法：这项前瞻性随机双盲研究在计划进行结肠镜检查的62位18-82岁的成年人中进行。患者分为两组，A组（n = 31）在手术前接受咪达唑仑2.5–5.0 mg和喷他佐辛15–30 mg，而B组（n = 31）接受丙泊酚0.5 mg / kg和芬太尼0.5ug / kg。 。使用Ramsay镇静评分（RSS），疼痛评分和镇静恢复率通过镇静深度测量疗效，而通过心率，血压（BP）和血氧饱和度评估安全性。结果：两组在人口统计学和临床​​数据方面无统计学意义上的差异。与A组的2.07±0.74相比，B组的患者具有更高的镇静效果，平均RSS为4.1±0.79（P = 0.001）。手术过程中的平均疼痛评分在B组为3.19±1.9，而A组为4.8±1.9（P = 0.001）。与A组相比，B组的恢复时间更快，分别为24分钟和46分钟（P = 0.001）。 B组在5和10分钟时的收缩压较低（P = 0.024和P = 0.001），而在5和10分钟时的舒张压（P = 0.042和P = 0.04）较低。 B组中有6名患者出现低血压，而A组中有2名患者。两组的心率无差异。两组中的两名患者的去饱和度均<90％，并给予氧气以维持氧合。没有患者发生需要进行气管插管的呼吸暂停。结论：丙泊酚-芬太尼合剂具有更好的镇静作用，更少的痛苦操作，更短的恢复时间，并最大程度地减少了心肺并发症。

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