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首页> 外文期刊>Journal of clinical biochemistry and nutrition. >Recent Advances in Indian Herbal Drug Research Guest Editor: Thomas Paul Asir Devasagayam Physico-Chemical Studies on the Evaluation of the Antioxidant Activity of Herbal Extracts and Active Principles of Some Indian Medicinal Plants
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Recent Advances in Indian Herbal Drug Research Guest Editor: Thomas Paul Asir Devasagayam Physico-Chemical Studies on the Evaluation of the Antioxidant Activity of Herbal Extracts and Active Principles of Some Indian Medicinal Plants

机译：印度草药研究的最新进展特约编辑：Thomas Paul Asir Devasagayam评价草药提取物抗氧化活性的理化研究和一些印度药用植物的活性成分

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Understanding of the efficacy and mechanism for the reaction of the biologically important radicals with natural and/or synthetic antioxidants is the first step towards the development of future therapeutic agents. The kinetic parameters e.g., formation and decay rate constants predict the efficacy of an antioxidant and its fate after reaction. These parameters also dictate the ease with which competing reactions would occur in a bio-environment. The spectroscopic parameters provide the clue to the site of free radical attack to these antioxidants. Here, in this article an attempt has been made to show the use of physico-chemical methods in the evaluation of antioxidant activity of some important medicinal plants commonly used in India and the subcontinent. The systems chosen here for discussions are herbal extracts as such, curcumin from turmeric, methoxy phenols from Indian spices, dehydrogingerdione from ginger and bakuchiol from Psoralea corylifolia . All the examples shown in this article illustrate the potential of the pulse radiolysis coupled with kinetic spectroscopy and other physicochemical techniques for the study of antioxidants either in the form of mixture as in herbal extract or as an isolated compound.
机译：了解生物学上重要的自由基与天然和/或合成抗氧化剂反应的功效和机理是开发未来治疗剂的第一步。动力学参数，例如形成常数和衰变速率常数，可预测抗氧化剂的功效及其在反应后的命运。这些参数还决定了在生物环境中发生竞争反应的难易程度。光谱参数为这些抗氧化剂的自由基攻击位点提供了线索。在此，本文尝试显示了使用物理化学方法评估印度和次大陆常用的一些重要药用植物的抗氧化活性。这里讨论的系统是草药提取物，例如姜黄中的姜黄素，印度香料中的甲氧基苯酚，姜中的脱氢姜二酮和补骨脂中的补骨脂酚。本文中显示的所有示例都说明了脉冲放射分解与动力学光谱法和其他物理化学技术相结合的潜力，无论是以草药提取物的混合物形式还是以分离的化合物形式，都可以研究抗氧化剂。

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