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首页> 外文期刊>Journal of clinical laboratory analysis. >Is procalcitonin better than C-reactive protein for early diagnosis of bacterial pneumonia in children?
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Is procalcitonin better than C-reactive protein for early diagnosis of bacterial pneumonia in children?

机译：对儿童细菌性肺炎的早期诊断，降钙素原是否比C反应蛋白好？

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Early diagnosis of bacterial pneumonia plays a pivotal role in the management. We evaluated the diagnostic accuracy of procalcitonin (PCT) as compared with C-reactive protein (CRP) for the early diagnosis of bacterial pneumonia in children. In total, 92 children consisting of 46 patients of bacterial pneumonia were admitted in the Military hospital, Rawalpindi, Pakistan and equal number of controls were included. Patient's investigations were carried out at admission. PCT and CRP were analyzed on Vidas analyzer and Immulite 1000, respectively. Out of 46 pneumonia patients, 28 were male and 18 female, with a median age of 4 years. PCT levels were significantly high median (range) of 2.69 ng/ml (0.30-13.00) vs. 0.45 ng/ml (0.10-2.00) in controls. Serum CRP levels were moderately elevated with median (range) 6.5 mg/l (0.30-60) vs. 0.30 mg/l (0.30-5.0) in controls. The area under receiver characteristic curves for PCT and CRP were 0.89 (95% CI=0.83-0.96) and 0.79 (95% CI=0.70-0.88), respectively. In total, 38 patients were diagnosed to have bacterial pneumonia with PCT (sensitivity 83% at cutoff 1 ng/ml) and 26 children with CRP (sensitivity 57% at cutoff 6 mg/L). PCT has better diagnostic accuracy than CRP and can be utilized for early diagnosis of bacterial pneumonia in children. J. Clin. Lab. Anal. 24:1-5, 2010. ? 2010 Wiley-Liss, Inc.
机译：细菌性肺炎的早期诊断在管理中起着关键作用。我们评估了降钙素原（PCT）与C反应蛋白（CRP）相比对儿童细菌性肺炎的早期诊断的准确性。巴基斯坦拉瓦尔品第的军事医院总共收治了92名儿童，其中包括46名细菌性肺炎患者，其中包括相同数量的对照。患者入院时进行了检查。分别在Vidas分析仪和Immulite 1000上分析PCT和CRP。在46例肺炎患者中，男性28例，女性18例，中位年龄为4岁。 PCT水平显着较高的中位数（范围），为2.69 ng / ml（0.30-13.00），而对照组为0.45 ng / ml（0.10-2.00）。血清CRP水平适度升高，中位数（范围）为6.5 mg / l（0.30-60），而对照组为0.30 mg / l（0.30-5.0）。 PCT和CRP的接收器特征曲线下面积分别为0.89（95％CI = 0.83-0.96）和0.79（95％CI = 0.70-0.88）。总共38例被诊断患有PCT的细菌性肺炎（临界值1 ng / ml时为83％）和26例CRP儿童（临界值6 mg / L时为57％）。 PCT具有比CRP更好的诊断准确性，可用于儿童细菌性肺炎的早期诊断。 J.临床。实验室肛门2010年24：1-5。 2010 Wiley-Liss，Inc.

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