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首页> 外文期刊>Journal of Dentistry >Histological Evaluation of Wound Healing Process after Photodynamic Therapy of Rat Oral Mucosal Ulcer
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Histological Evaluation of Wound Healing Process after Photodynamic Therapy of Rat Oral Mucosal Ulcer

机译：光动力疗法治疗大鼠口腔粘膜溃疡后伤口愈合过程的组织学评价

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Statement of the Problem: When the body defense is compromised, wounds can act as a route for entrance and colonization of microorganisms in the body. Photodynamic therapy with methylene blue is known as a promising antimicrobial modality. Purpose: The present study aimed to investigate the effects of this procedure on wound healing processes. Materials and Method: In this experimental study, 48 male Wistar rats were recruited. Experimental wounds were surgically made on their buccal mucosa. Based on the treatment modality, they were divided into 3 groups (n=16) of control (CG), laser (LG), photosensitizer+ laser (PLG) by methylene blue (MB). The treatment procedure in the two latter groups was done in days 1-4 and 6-9. After sacrificing on 2, 4, 7 and 14-day follow-ups, the microscopic grade of healing of the wounds was assigned on each interval according to histological grading criteria. Results: A qualitative result was obtained that showed a healing progression in PLG at day 2 of follow-up. At day 4 of follow-up, no difference was seen in healing stage among the groups. However on day 7 of follow-up, samples of the LG showed a lower degree of healing compared with the other two groups. Likewise, on day 14 of follow- up, both PLG and LG showed lower degree of healing than CG. Conclusion: This study qualitatively showed that MB- mediated photodynamic therapy would have an inhibitory effect on healing process after 14 days of the wound creation. Key Words: Laser; Methylene Blue; Photodynamic Therapy; Wound Healing
机译：问题陈述：当人体防御能力受损时，伤口可以作为微生物进入并在体内定殖的途径。亚甲基蓝的光动力疗法被称为一种有前途的抗菌方式。目的：本研究旨在研究该方法对伤口愈合过程的影响。材料和方法：在本实验研究中，招募了48只雄性Wistar大鼠。实验性伤口是在其颊粘膜上进行手术处理的。根据治疗方式，通过亚甲基蓝（MB）将其分为对照组（CG），激光（LG），光敏剂+激光（PLG）3组（n = 16）。后两组的治疗程序在1-4和6-9天完成。在第2、4、7和14天的随访中牺牲后，根据组织学分级标准在每个间隔上指定伤口愈合的微观等级。结果：获得定性结果，显示随访第二天PLG的愈合进展。在随访的第4天，各组在愈合阶段均无差异。然而，在随访的第7天，与其他两组相比，LG样品的愈合程度较低。同样，在随访的第14天，PLG和LG的愈合程度均低于CG。结论：该研究定性显示MB介导的光动力疗法在创面14天后对愈合过程具有抑制作用。关键词：激光亚甲蓝;光动力疗法;伤口愈合

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