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首页> 外文期刊>Journal of Dentistry of Tehran University of Medical Sciences >THE EFFECT OF ANTIMICROBIAL PHOTODYNAMIC THERAPY WITH RADACHLORIN AND TOLUIDINE BLUE ON STREPTOCOCCUS MUTANS: AN IN VITRO STUDY
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THE EFFECT OF ANTIMICROBIAL PHOTODYNAMIC THERAPY WITH RADACHLORIN AND TOLUIDINE BLUE ON STREPTOCOCCUS MUTANS: AN IN VITRO STUDY

机译：RADACHLORIN和甲苯胺蓝对抗菌药物的光动力学治疗对鼠链球菌的体外研究

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Objectives: Dental caries and periodontal diseases are caused by infection of teeth and supporting tissues due to complex aggregate of bacteria known as biofilm, firstly colonized by streptococci. The main purpose of this in vitro study was to evaluate the antimicrobial effects of toluidine blue O (TBO) and Radachlorin? in combination with a diode laser on the viability of Streptococcus mutans.Materials and Methods: Bacterial suspensions of Streptococcus mutans were exposed to either 0.1% TBO associated with (20 mW, 633 nm diode laser, continuous mode, 150 s) or 0.1% Radachlorin? and laser irradiation (100 mW, 662 nm diode laser, continuous mode, 120 s). Those in control groups were subjected to laser irradiation alone or TBO/Radachlorin? alone or received neither TBO/Radachlorin? nor laser exposure. The suspensions were then spread over specific agar plates and incubated aerobically at 37oC. Finally, the bactericidal effects were evaluated based on colony formation.Results: Potential bacterial cell killing was only observed following photosensitization with TBO and 3 j/cm2 laser exposure (pConclusion: TBO-mediated photodynamic therapy seems to be more efficient than Radachlorin ? in significantly reducing the viability of Streptococcus mutans in vitro.
机译：目的：龋齿和牙周疾病是由于细菌和支持组织的感染而引起的，这种感染是由于被称为生物膜的细菌的复杂聚集所致，首先是被链球菌所定殖。这项体外研究的主要目的是评估甲苯胺蓝O（TBO）和Radachlorin？的抗菌作用。材料和方法：将变形链球菌的细菌悬液暴露于0.1％TBO伴随下（20 mW，633 nm二极管激光器，连续模式，150 s）或0.1％Radachlorin ？和激光照射（100 mW，662 nm二极管激光器，连续模式，120 s）。对照组的患者单独接受激光照射或使用TBO / Radachlorin？单独服用还是未接受TBO / Radachlorin？也不进行激光曝光。然后将悬浮液铺展在特定的琼脂平板上，并在37℃下进行有氧培养。结果：仅在用TBO和3j / cm 2 激光照射光敏后才观察到潜在的细菌细胞杀伤作用（p结论：TBO介导的光动力疗法似乎可以比Radachlorin？更有效地显着降低了变形链球菌在体外的生存能力。

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