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首页> 外文期刊>Journal of diabetes investigation. >Comparison of four cardiovascular risk prediction functions among Chinese patients with diabetes mellitus in the primary care setting
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Comparison of four cardiovascular risk prediction functions among Chinese patients with diabetes mellitus in the primary care setting

机译：中国基层糖尿病患者四种心血管风险预测功能的比较

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AbstractAims/IntroductionTo assess the feasibility, convergent validity and sensitivity of four cardiovascular risk prediction functions in Chinese diabetic patients in the primary care setting.Materials and MethodsA cross-sectional study of 1,140 diabetic patients was carried out to compare four cardiovascular risk functions, which were respectively developed from the Framingham heart study, the USA–People's Republic of China Collaborative Study of Cardiovascular and Cardiopulmonary Epidemiology cohort (PRC), the United Kingdom Prospective Diabetes Study (UKPDS) and the Joint Asia Diabetes Evaluation program (JADE). Feasibility was assessed by the percentage of patients with complete data for risk prediction. Convergent validity was measured by Spearman's rank correlation, paired Wilcoxon signed-rank sum test and Bland–Altman plots. Effect size differences between clinical risk groups were used to assess the sensitivity.ResultsRisk prediction was feasible by the Framingham, UKPDS and PRC risk functions in more than 98% patients, whereas just 74% of patients had complete data for the JADE function. The annual total coronary heart disease (CHD) risk predicted by the JADE and the UKPDS functions showed excellent agreement with no significant difference, and a correlation of 0.8048. The Framingham and the PRC functions predicted significantly lower CHD risk than those by the UKPDS and the JADE functions. The UKPDS and the Framingham functions were more sensitive in differentiating clinical risk groups.ConclusionsThe UKPDS risk engine showed good feasibility, convergent validity and sensitivity in predicting CHD risk in Chinese diabetic patients. The JADE function showed excellent agreement with the UKPDS risk engine, but it was less feasible in the primary care setting.
机译：摘要目的/简介为了评估在初级保健机构中中国糖尿病患者四种心血管风险预测功能的可行性，收敛效度和敏感性。材料与方法对1,140名糖尿病患者进行横断面研究，以比较四种心血管风险预测功能。分别从Framingham心脏研究，美国与中国心血管和心肺流行病学研究队列（PRC），英国前瞻性糖尿病研究（UKPDS）和亚洲糖尿病联合评估计划（JADE）共同开发。通过具有用于风险预测的完整数据的患者百分比来评估可行性。收敛效度通过Spearman秩相关，成对的Wilcoxon符号秩和检验和Bland-Altman图进行度量。结果：通过Framingham，UKPDS和PRC风险函数对98％以上的患者进行风险预测是​​可行的，而只有74％的患者具有JADE函数的完整数据。 JADE和UKPDS功能预测的年度总冠心病（CHD）风险显示出极好的一致性，无显着差异，且相关性为0.8048。与UKPDS和JADE职能相比，Framingham和PRC职能预测的冠心病风险显着降低。 UKPDS和Framingham功能在区分临床风险组中更为敏感。结论UKPDS风险引擎在预测中国糖尿病患者冠心病风险方面显示出良好的可行性，收敛性和敏感性。 JADE功能与UKPDS风险引擎显示出极好的一致性，但在基层医疗机构中不太可行。

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