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首页> 外文期刊>Journal of Diabetes and Metabolic Disorders >Prevalence of vitamin D deficiency across the spectrum of glucose intolerance
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Prevalence of vitamin D deficiency across the spectrum of glucose intolerance

机译:在葡萄糖不耐症谱图中普遍存在维生素D缺乏症

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Background Vitamin D deficiency (VDD) is inversely associated with insulin resistance. We studied the prevalence of VDD across the spectrum of glucose intolerance, including normal glucose tolerance (NGT), prediabetes (PD) and type 2 diabetes (T2D). Methods We conducted this cross-sectional, observational study by serially including the PD and T2D patients seen between June and December 2014. We excluded patients with major illness, secondary diabetes and use of vitamin D or glucocorticoids. VDD was defined as serum 25-hydroxy vitamin D (25OHD) less than 30 ng/mL. The study population was divided into 3 groups: T2D (Group 1; n?=?274), PD (Group 2; n?=?62) and NGT controls (Group 3; n?=?270) for the analysis and appropriate statistical methods were used. Results The study participants (n?=?606, 28 % males) had a mean age of 43.2?±?13.6 years, BMI of 27.7?±?5.9 kg/m 2 , HbA1c of 6.6?±?2 % and mean 25OHD of 18.8?±?15.7 ng/mL. VDD was seen in 85 % of the entire study population including 84 % in T2D, 77 % in prediabetes and in 87 % of the controls. The mean 25OHD levels were lower in the control group (16.8 ng/mL) when compared with T2D and prediabetes (19.9 and 22.4 ng/mL) respectively (P?=?0.0124). Univariate analysis showed higher odds of VDD in females (P?
机译:背景维生素D缺乏症(VDD)与胰岛素抵抗呈负相关。我们研究了葡萄糖耐量谱中的VDD患病率,包括正常的葡萄糖耐量(NGT),糖尿病前期(PD)和2型糖尿病(T2D)。方法我们对2014年6月至2014年12月之间的PD和T2D患者进行了连续的横断面观察研究。我们排除了患有重病,继发性糖尿病以及使用维生素D或糖皮质激素的患者。 VDD被定义为血清30-羟基维生素D(25OHD)小于30 ng / mL。研究人群分为3组:T2D(第1组; n?=?274),PD(第2组; n?=?62)和NGT对照(第3组; n?=?270)进行分析,并进行适当分析使用统计方法。结果研究参与者(n == 606,男性占28%)的平均年龄为43.2±13.6岁,BMI为27.7±±5.9 kg / m 2,HbA1c为6.6±±2%,平均25OHD为18.8±15.7ng / mL。在整个研究人群中有85%观察到VDD,其中84%的T2D患者,77%的糖尿病患者和87%的对照患者。对照组的平均25OHD水平(16.8 ng / mL)低于T2D和糖尿病前期(19.9和22.4 ng / mL)(P <= 0.0124)。单因素分析显示女性VDD的几率更高(P 0.0001),但与糖尿病,年龄,BMI和HbA1c无关。结论我们的数据表明VDD在大多数人群中都普遍存在,而与潜在的葡萄糖耐量无关。需要进一步的研究以确定维生素D与糖尿病之间的关联。

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