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首页> 外文期刊>Journal of Diabetes and Metabolic Disorders >Dry eye disease in type 2 diabetes mellitus; comparison of the tear osmolarity test with other common diagnostic tests: a diagnostic accuracy study using STARD standard
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Dry eye disease in type 2 diabetes mellitus; comparison of the tear osmolarity test with other common diagnostic tests: a diagnostic accuracy study using STARD standard

机译：2型糖尿病的干眼症;渗透压测试与其他常见诊断测试的比较：使用STARD标准的诊断准确性研究

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Background To determine the diagnostic performance of tear osmolarity in diagnosis of dry eye disease by using tear lab osmolarity system in people with type 2 diabetes, and to compare it with common diagnostic tests already available in clinical practice. Methods Two hundreds forty three people with type 2 diabetes were included. Tear osmolarity was measured with the tear osmolarity system. The 308 mOsm/L cutoff was used to diagnose dry eye disease. The following tests were also performed: Ocular Surface Disease Index (OSDI) questionnaire, Tear Film Break up Time (TFBUT), Schirmer I test, Rose Bengal and Fluorescein staining. The results of these tests were compared to the tear osmolarity measurement. Results The prevalence of dry eye disease detected by the tear osmolarity test was 27.7%. It was as follows for the other common diagnostic tests: OSDI (17.7%), Schirmer I test (33%), TFBUT (41%), Rose Bengal (11%), and Fluorescein staining (4%). Fluorescein staining had the highest specificity (97%). With the cutoff score >12, the positive likelihood ratio for the OSDI questionnaire was the highest (1.78). The sensitivity was poor for all common diagnostic tests. ROC curve analysis could not determine optimal cut offs for the common diagnostic tests. Conclusions The available common diagnostic tests underestimate the presence of dry eye disease in people with type 2 diabetes. Moreover, they could not discriminate tear hyperosmolarity from normal. Tear osmolarity could be considered as the best single test for detection of dry eye disease in people with type2 diabetes.
机译：背景技术通过使用2型糖尿病患者的眼泪实验室渗透压系统确定泪液渗透压在干眼病诊断中的诊断性能，并将其与临床实践中已经可用的常见诊断测试进行比较。方法纳入243例2型糖尿病患者。泪液渗透压用泪液渗透压系统测量。 308 mOsm / L的临界值用于诊断干眼症。还进行了以下测试：眼表疾病指数（OSDI）问卷，泪膜破裂时间（TFBUT），Schirmer I测试，孟加拉红和荧光素染色。将这些测试的结果与泪液渗透压测量值进行比较。结果泪液渗透压试验检测出的干眼病患病率为27.7％。其他常见诊断测试结果如下：OSDI（17.7％），Schirmer I测试（33％），TFBUT（41％），Rose Bengal（11％）和荧光素染色（4％）。荧光素染色的特异性最高（97％）。截止得分> 12，OSDI问卷的正似然比最高（1.78）。对于所有常见的诊断测试，灵敏度均较差。 ROC曲线分析无法确定常见诊断测试的最佳临界值。结论现有的常见诊断测试低估了2型糖尿病患者中干眼症的存在。而且，他们无法区分泪液渗透压与正常。眼泪渗透压可被视为检测2型糖尿病患者干眼病的最佳单一测试。

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