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首页> 外文期刊>Journal of Diabetes and Metabolic Disorders >Relationship of resting heart rate and physical activity with insulin sensitivity in a population-based survey
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Relationship of resting heart rate and physical activity with insulin sensitivity in a population-based survey

机译：基于人群的调查中静息心率和体育锻炼与胰岛素敏感性的关系

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Background Resting heart rate (RHR) has been identified as an independent risk factor for cardiovascular disease and mortality, contributing to atherosclerosis, the progression of heart failure, and myocardial ischemia and infarction. This study examines the association RHR and physical activity has with insulin resistance and insulin secretion in a multiethnic cohort from North Kohala, Hawai‘i. Methods Cross-sectional data from 1,440 participants of Native Hawaiian, Japanese, Filipino, Caucasian, and mixed ethnic ancestries were analyzed for the study to include anthropometric measurements, and biochemical markers. Body fat was estimated by calculating body mass indices (BMI); body fat distribution by waist-hip ratios (WHR); and fasting plasma glucose and insulin levels were used to calculate insulin resistance using the Homeostasis Model (HOMA-IR). First phase insulin response was estimated using the insulin secretion ratio (ISR). Associations were estimated using general linear models (GLM). Results Caucasians had lower mean RHR than all other ethnic groups; there were no statistically significant differences between other ethnic groups on mean RHR. HOMA-IR was associated with ethnic group, BMI and WHR, PA and RHR, while ISR was associated with age, ethnic group and BMI, but none of the primary risk factors. Both RHR and physical activity level remained significant for insulin resistance. Conclusions In a multiethnic cohort from a rural community in Hawai‘i, increased RHR and a lower level of physical activity were both independently associated with increased risk for the development of insulin resistance, suggesting cardiovascular fitness may be as important as physical activity in preventing insulin resistance.
机译：背景技术静息心率（RHR）已被确定为心血管疾病和死亡率的独立危险因素，可导致动脉粥样硬化，心力衰竭的进展以及心肌缺血和梗塞。这项研究调查了来自夏威夷北科阿拉的多种族队列中RHR和体力活动与胰岛素抵抗和胰岛素分泌之间的关系。方法对来自1,440名夏威夷土著人，日本人，菲律宾人，白种人和混合种族祖先的参与者的横断面数据进行分析，包括人体测量和生化标记。通过计算体重指数（BMI）估算身体脂肪;腰臀比（WHR）显示人体脂肪分布;空腹血糖和胰岛素水平用于根据稳态模型（HOMA-IR）计算胰岛素抵抗。使用胰岛素分泌率（ISR）估算第一阶段胰岛素反应。使用通用线性模型（GLM）估计关联。结果高加索人的平均RHR低于所有其他种族;其他种族在平均RHR上没有统计学上的显着差异。 HOMA-IR与种族，BMI和WHR，PA和RHR相关，而ISR与年龄，种族和BMI相关，但没有主要危险因素。 RHR和体力活动水平对于胰岛素抵抗均保持显着水平。结论在夏威夷农村社区的一个多种族队列中，RHR升高和体育锻炼水平降低均与胰岛素抵抗发生风险增加相关，这表明心血管健康与体育锻炼在预防胰岛素方面同样重要抵抗性。

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