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首页> 外文期刊>Dementia and Geriatric Cognitive Disorders Extra >Novel Face-Name Paired Associate Learning and Famous Face Recognition in Mild Cognitive Impairment: A Neuropsychological and Brain Volumetric Study
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Novel Face-Name Paired Associate Learning and Famous Face Recognition in Mild Cognitive Impairment: A Neuropsychological and Brain Volumetric Study

机译：轻度认知障碍中的新型面孔名称配对学习和著名面孔识别：神经心理学和脑容量研究

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Purpose: To assess visual associative learning and famous face recognition ability among subjects with stable amnestic mild cognitive impairment (MCI) relative to early stage dementia due to Alzheimer’s disease (AD) and cognitively normal healthy controls (NC) and to correlate these differences with volumetric changes on MRI. Methods: A hospital-based cross-sectional observational study was conducted on 61 participants. The subjects underwent neuropsychological evaluation, including validated newly designed tests for novel face-name paired association learning recall and famous face recognition. MRI volumetry was done on a subset of patients to ascertain the topographical patterns of volume loss. Results: There were significant differences in performance on free recall for face-name paired associate learning in MCI (n = 22) compared to NC (n = 20) (p 0.001) and MCI compared to AD (n = 19; p 0.001). Significant differences were also noted in scores on the famous personalities test between MCI and NC (p = 0.007), and MCI and AD (p = 0.032). The free recall component of face-name pair associative learning significantly correlated with left cuneus (p = 0.005; r = 0.833) and right cuneus (p = 0.003; r = 0.861) volume in AD with no significant correlation among MCI and NC cohorts. Conclusions: Novel and semantically familiar face-name associative recalls are significantly impaired in MCI, and these potentially predate the MRI volumetric changes in MCI. Our findings expand the spectrum of recall deficits in MCI.
机译：目的：评估与阿尔茨海默氏病（AD）和认知正常健康对照（NC）引起的早期痴呆相关的轻度轻度认知障碍（MCI）稳定的受试者的视觉联想学习和著名的面部识别能力，并将这些差异与容量相关联MRI的改变。方法：对61名参与者进行了一项基于医院的横断面观察研究。受试者接受了神经心理学评估，包括经过验证的新设计的测试，用于测试新面孔识别配对联想记忆和著名面孔识别。对一部分患者进行了MRI容积测定，以确定容积损失的地形图。结果：MCI（n = 22）与NC（n = 20）（p <0.001）和MCI与AD（n = 19; p < 0.001）。 MCI和NC（p = 0.007），MCI和AD（p = 0.032）之间的著名人格测验得分也存在显着差异。人名对联想学习的自由回忆成分与AD中左楔骨（p = 0.005; r = 0.833）和右楔骨（p = 0.003; r = 0.861）的量显着相关，而MCI和NC队列之间无显着相关性。结论：在MCI中，新的和在语义上熟悉的面部名称联想召回显着受损，并且这些可能早于MCI的MRI容积变化。我们的发现扩大了MCI中召回缺陷的范围。

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