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首页> 外文期刊>Journal of epidemiology / >Association between Smoking Habits and Tryptophan Hydroxylase Gene C218A Polymorphism among the Japanese Population
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Association between Smoking Habits and Tryptophan Hydroxylase Gene C218A Polymorphism among the Japanese Population

机译：吸烟习惯与日本人群色氨酸羟化酶基因C218A多态性的关联。

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BACKGROUND: Genetic polymorphisms have proposed a new insight in smoking behavior. Genes in serotonin system are one of the candidates because of serotonin's role in mood regulation. A polymorphism C218A in intron 7 of the tryptophan hydroxylase ( TPH ) gene has been hypothesized in relation to smoking predisposition. METHODS: We examined the association on two Japanese populations: one was from the first-visit outpatients of Aichi Cancer Center Hospital during 3-month period between April and June, 2001 (N=591), and the second was from the examinees who attended a health checkup program supported by the Nagoya municipal government in 2000 (N=446). Written documents on informed consent were obtained and lifestyle questionnaires were recorded. TPH C218A genotypes were determined by the polymerase chain reaction with confronting two-pair primers (PCR-CTPP) method. RESULTS: The frequencies of the C - and A -allele were 52% and 48%, respectively, which was in Hardy-Weinberg equilibrium. As for current smoking status, no associations were statistically observed. It was, however, indicated that smokers with A / A genotype started smoking earlier in their life. Among male health examinees, mean ages at starting smoking were 18.7 ( A / A ), 19.9 ( C / A ), and 22.4 years ( C / C ), (P<0.01). Also, on the Aichi Cancer Center Hospital subjects aged 60 and older, mean ages were 19.0 ( A / A ), 20.2 ( C / A ), and 20.3 years ( C / C ) for males and 22.3 ( A / A ), 31.0 ( C / A ), and 33.0 years ( C / C ) for females (P<0.05). CONCLUSIONS: The present study demonstrated that the TPH C218A polymorphism in intron 7 had no association with current smoking status in Japanese population. The hypothesis of early smoking initiation of A / A genotype was partially in agreement.
机译：背景：遗传多态性已提出吸烟行为的新见解。由于5-羟色胺在情绪调节中的作用，5-羟色胺系统中的基因是候选之一。色氨酸羟化酶（TPH）基因内含子7中的一个多态性C218A已被假设与吸烟易感性有关。方法：我们检查了两个日本人群的相关性：一个来自爱知癌症中心医院在2001年4月至2001年6月的三个月内首次就诊的患者（N = 591），第二个来自就诊的受检者名古屋市政府于2000年支持的一项健康检查计划（N = 446）。获得知情同意的书面文件，并记录生活方式问卷。 TPH C218A基因型通过面对两对引物的聚合酶链反应（PCR-CTPP）方法确定。结果：C-和A-等位基因的频率分别为52％和48％，处于Hardy-Weinberg平衡状态。至于目前的吸烟状况，没有统计学上的关联性。但是，这表明具有A / A基因型的吸烟者在其生命早期就开始吸烟。在男性健康检查者中，开始吸烟的平均年龄为18.7（A / A），19.9（C / A）和22.4岁（C / C），（P <0.01）。另外，爱知县癌症中心医院的60岁及60岁以上的男性平均年龄分别为19.0（A / A），20.2（C / A）和20.3（C / C）和22.3（A / A），31.0 （C / A），女性为33.0岁（C / C）（P <0.05）。结论：本研究表明内含子7中的TPH C218A多态性与日本人群当前的吸烟状况无关。早期吸烟引发A / A基因型的假说在一定程度上是一致的。

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