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首页> 外文期刊>Dementia and Geriatric Cognitive Disorders Extra >Asymmetric Cerebral Blood Flow in Patients with Mild Cognitive Impairment: Possible Relationship to Further Cognitive Deterioration
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Asymmetric Cerebral Blood Flow in Patients with Mild Cognitive Impairment: Possible Relationship to Further Cognitive Deterioration

机译：轻度认知障碍患者的脑血流不对称：可能与进一步的认知功能恶化有关

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Aim: To explore patterns of cerebral blood flow in patients with mild cognitive impairment (MCI), who (1) eventually deteriorate into overt dementia, with no particular focus on the type of dementia, or (2) do not appear to further deteriorate in their cognitive functions. Methods: Thirty-seven MCI patients, with or without vascular pathology, were studied prospectively. The patients underwent 99mTc-HMPAO SPECT analysis at baseline. Possible clinical conversion into dementia within a 2-year period was assessed. Results: Nineteen patients had progressive MCI (PMCI), while 18 patients were considered clinically stable (SMCI). PMCI patients had more often abnormally low cerebral blood flow in at least one of the frontal, temporal, parietal or occipital lobes compared to SMCI patients (12/19 vs. 5/18; p = 0.049). At least one of the temporal regions was found to be abnormal in 9 PMCI patients in contrast to only 1 SMCI patient (p = 0.008). More specifically, blood flow in the medial portion of the left temporal region was abnormal in 8 PMCI patients, a pattern seen in 1 SMCI patient only (p = 0.019). Conclusion: The results suggest that blood flow reductions particularly in the left medial temporal region indicate an elevated risk of further cognitive decline in MCI patients.
机译：目的：探讨轻度认知障碍（MCI）患者的脑血流模式，这些患者（1）最终恶化为明显的痴呆症，而没有特别关注痴呆的类型，或者（2）似乎并未进一步恶化。他们的认知功能。方法：前瞻性研究了37例有或无血管病变的MCI患者。基线时对患者进行 99m Tc-HMPAO SPECT分析。评估了2年内可能转化为痴呆的临床可能。结果：19例进行性MCI（PMCI），而18例被认为是临床稳定（SMCI）。与SMCI患者相比，PMCI患者在额叶，颞叶，顶叶或枕叶中至少其中之一的大脑血流异常异常多（12/19 vs. 5/18; p = 0.049）。与仅1名SMCI患者相比，在9名PMCI患者中至少发现了一个颞区异常（p = 0.008）。更具体地说，在8例PMCI患者中，左颞部内侧部分的血流异常，仅在1例SMCI患者中可见（P = 0.019）。结论：结果表明，MCI患者尤其是左内侧颞区的血流量减少表明进一步认知下降的风险增加。

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