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首页> 外文期刊>Dementia and Geriatric Cognitive Disorders Extra >Long Latency and High Variability in Accuracy-Speed of Prosaccades in Alzheimer’s Disease at Mild to Moderate Stage
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Long Latency and High Variability in Accuracy-Speed of Prosaccades in Alzheimer’s Disease at Mild to Moderate Stage

机译：轻度至中度阶段阿尔茨海默氏病患者s发的准确度高，时延长且变异大

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Background: Studying saccades is a useful tool to investigate brain function. There is still controversy regarding deficits in prosaccades in Alzheimer’s disease (AD), and a study of saccades in subjects with mild cognitive impairment (MCI) has not been published to date. Methods: We examined horizontal saccades in 10 healthy elderly, and 9 MCI and 9 AD patients. Two tasks were used: gap (fixation target extinguishes prior to target onset) and overlap (fixation stays on after target onset). Eye movements were recorded with the Skalar IRIS system. Results: (1) Latencies were shorter in the gap than in the overlap task (a gap effect) in all three groups of subjects: healthy elderly, MCI and AD; (2) for both tasks, latency of saccades was longer for AD patients than for healthy and MCI subjects, and (3) accuracy and mean velocity were normal in MCI and AD subjects, however, variability in accuracy-speed was higher for AD patients than for healthy and MCI subjects in the overlap task. Conclusions: Abnormalities in reaction time and accuracy-speed variability reflect deficits in cerebral areas involved in the triggering and execution of saccades; a saccade test can be useful to follow up the evolution of MCI subjects as some of them may develop AD disease.
机译：背景：研究扫视是研究脑功能的有用工具。关于阿尔茨海默氏病（AD）的前瞻性障碍的争议仍然存在争议，迄今为止，尚未发表关于轻度认知障碍（MCI）受试者中前瞻性昏迷的研究。方法：我们检查了10名健康老年人，9名MCI和9名AD患者的水平扫视。使用了两项任务：缝隙（固定目标在目标发作之前熄灭）和重叠（固定在目标开始后保持固定）。用Skalar IRIS系统记录眼动。结果：（1）在所有三类受试者中，健康者，MCI和AD患者的间隙潜伏期短于重叠任务（间隙效应）。 （2）在这两项任务中，AD患者的扫视潜伏期都比健康人和MCI受试者更长，并且（3）MCI和AD受试者的准确性和平均速度均正常，但是AD患者的准确性-速度差异较大胜过健康和MCI受试者的重叠任务。结论：反应时间和准确度-速度变异性的异常反映了参与扫视的触发和执行的大脑区域的缺陷。扫视测试可能有助于追踪MCI受试者的进化，因为其中一些受试者可能会发展为AD疾病。

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