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首页> 外文期刊>Age. >Specific saccade deficits in patients with Alzheimer's disease at mild to moderate stage and in patients with amnestic mild cognitive impairment.
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Specific saccade deficits in patients with Alzheimer's disease at mild to moderate stage and in patients with amnestic mild cognitive impairment.

机译：在轻度至中等阶段和患有Amnestic认知障碍患者的阿尔茨海默病患者的特定扫视缺陷。

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摘要

Saccadic impairment in Alzheimer's disease (AD) was found in horizontal saccades. The present study extends investigation to vertical saccades in a large number of subjects, including AD and amnestic mild cognitive impairment (aMCI). We examined both horizontal and vertical saccades in 30 healthy elderly, 18 aMCI, and 25 AD. Two tasks were used: gap (fixation target extinguishes prior to target onset) and overlap (fixation stays on after target onset). Eye movements were recorded with the Eyeseecam system. (1) Robust gap effect (shorter latencies in gap than in overlap) exists for AD and aMCI patients as for healthy elderly; (2) abnormal long latency of saccades in gap and overlap tasks for AD relative to healthy elderly and aMCI patients; (3) longer latency for aMCI patients than for healthy elderly for the overlap task; (4) significant correlation between scores of Mini-Mental State Examination (MMSE) and latencies of saccades considering the AD group only; (5) higher coefficient of variation in latency for AD patients than for healthy elderly and for aMCI patients; (6) variability of accuracy and speed is abnormally higher in AD patients than in aMCI and healthy elderly. Abnormalities of latency and latency-accuracy-speed variability reflect deficits of cerebral areas involved in the triggering and execution of saccades; latency of saccades can be used as follow-up test for aMCI and AD patients with its significant correlation with the changes of MMSE scores.
机译：在水平扫描中发现阿尔茨海默病（AD）的扫视障碍。本研究扩展了对大量科目的垂直扫描的调查，包括广告和Amnestic认知障碍（AMCI）。我们在30名健康的老年人，18个AMCI和25广告中审查了水平和垂直扫描。使用了两项任务：间隙（固定目标在目标发作前熄灭）和重叠（固定在目标发作后停留）。用Eyeseecam系统记录眼睛运动。 （1）适用于健康老年人的AD和AMCI患者存在强大的差距效应（比重叠间隙的较短延迟）; （2）相对于健康老年人和AMCI患者的间隙中扫视和重叠任务的扫视率异常延迟; （3）AMCI患者的延迟延迟而不是重叠任务的健康老年人; （4）仅考虑广告组的迷你精神状态检查（MMSE）和扫视延迟之间的显着相关性; （5）AD患者潜伏期潜伏期的变化系数较高，而不是健康的老年人和AMCI患者; （6）AD患者的精度和速度的可变性比AMCI和健康的老年人在异常更高。潜伏期和延迟 - 精度速度变异性的异常反映了横发和执行扫描的脑区的缺陷;扫视的潜伏期可用作AMCI和AD患者的后续测试与MMSE分数的变化具有显着相关性。

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