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首页> 外文期刊>Dementia and Geriatric Cognitive Disorders Extra >Brain Alterations and Mini-Mental State Examination in Patients with Progressive Supranuclear Palsy: Voxel-Based Investigations Using 18F-Fluorodeoxyglucose Positron Emission Tomography and Magnetic Resonance Imaging
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Brain Alterations and Mini-Mental State Examination in Patients with Progressive Supranuclear Palsy: Voxel-Based Investigations Using 18F-Fluorodeoxyglucose Positron Emission Tomography and Magnetic Resonance Imaging

机译：进行性核上性神经麻痹患者的脑部改变和微弱精神状态检查：使用18F-氟脱氧葡萄糖正电子发射断层显像和磁共振成像的基于体素的研究

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Background/Aims: The aim of this study was to compare differences in morphological and functional changes in brain regions in individual patients with progressive supranuclear palsy (PSP) and correlate their Mini-Mental State Examination (MMSE) score with anatomy and function using magnetic resonance imaging (MRI) and 18F-fluorodeoxyglucose positron emission tomography (FDG-PET). Methods: Sixteen PSP patients and 20 age-matched healthy volunteers underwent FDG-PET and 3-dimensional MRI. Gray matter, white matter and metabolic activity were compared between patients and normal controls. In addition, possible correlations between the MMSE score and brain function/anatomy were examined. Results: The PSP group had reduced cerebral glucose metabolism, and lower gray and white matter volumes in the frontal lobes and midbrain compared with normal controls. In PSP subjects, the metabolic changes observed in the PET scans were greater than the loss in gray and white matter observed in the MRI scans. The MMSE scores were positively correlated with volume and FDG uptake in the frontal lobe. Conclusion: FDG-PET is a more effective tool in the diagnosis of PSP than MRI. Atrophy and hypometabolism in the frontal lobe are as important as in the basal midbrain for differentiating PSP patients who primarily exhibit cognitive dysfunction from normal controls.
机译：背景/目的：本研究的目的是比较进行性核上性麻痹（PSP）的个别患者大脑区域的形态和功能变化的差异，并通过磁共振将他们的小精神状态检查（MMSE）评分与解剖学和功能相关联成像（MRI）和 18 F-氟脱氧葡萄糖正电子发射断层扫描（FDG-PET）。方法：对16例PSP患者和20例年龄相匹配的健康志愿者进行了FDG-PET和3维MRI检查。比较患者和正常对照组的灰质，白质和代谢活性。此外，还检查了MMSE评分与脑功能/解剖结构之间的可能相关性。结果：与正常对照组相比，PSP组脑葡萄糖代谢降低，额叶和中脑灰质和白质体积降低。在PSP受试者中，在PET扫描中观察到的代谢变化大于在MRI扫描中观察到的灰白物质损失。 MMSE评分与额叶的体积和FDG摄取呈正相关。结论：FDG-PET比PMRI更能有效地诊断PSP。额叶萎缩和低代谢与基底中脑一样重要，以区分主要表现出认知功能障碍和正常对照的PSP患者。

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