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首页> 外文期刊>Dementia and Geriatric Cognitive Disorders Extra >A Longitudinal SPECT Study of Different Patterns of Regional Cerebral Blood Flow in Alzheimer’s Disease with or without Diabetes
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A Longitudinal SPECT Study of Different Patterns of Regional Cerebral Blood Flow in Alzheimer’s Disease with or without Diabetes

机译：带有或不带有糖尿病的阿尔茨海默氏病不同区域性脑血流模式的纵向SPECT研究

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Aims: To determine the effect of diabetes mellitus (DM) on regional cerebral blood flow (rCBF) patterns in patients with Alzheimer’s disease (AD). Methods: We investigated the initial rCBF of 71 AD patients (36 without DM and 35 with DM) and the final rCBF of 23 AD patients (12 without DM and 11 with DM) after an average of 32 months. Single-photon emission computed tomography (SPECT) data were analyzed by statistical brain imaging. Results: The initial SPECT showed that AD patients without DM had lower rCBF in the left and right inferior temporal gyri than AD patients with DM. A follow-up SPECT demonstrated that rCBF decreased in more widespread regions, including the parietal, temporal, frontal, and limbic lobes, in AD patients without than with DM. Conclusion: This study suggests that functional brain abnormalities in AD differ depending on the DM status at baseline and during follow-up, reflecting neuropathologic differences.
机译：目的：确定糖尿病（DM）对阿尔茨海默病（AD）患者局部脑血流（rCBF）模式的影响。方法：我们调查了平均32个月后的71名AD患者的初始rCBF（36名无DM和35名DM）和23名AD患者（12名无DM和11名DM）的最终rCBF。通过统计脑成像分析单光子发射计算机断层扫描（SPECT）数据。结果：最初的SPECT显示，没有DM的AD患者的左右颞下回中的rCBF低于患有DM的AD患者。 SPECT的后续研究表明，与DM相比，AD患者的rCBF在更广泛的区域下降，包括顶叶，颞叶，额叶和边缘叶。结论：这项研究表明，AD的功能性脑异常取决于基线和随访期间的DM状态，从而反映出神经病理学差异。

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