• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Dementia and Geriatric Cognitive Disorders Extra >Blood Concentrations of Homocysteine and Methylmalonic Acid among Demented and Non-Demented Swedish Elderly with and without Home Care Services and Vitamin B12 Prescriptions
【24h】

Blood Concentrations of Homocysteine and Methylmalonic Acid among Demented and Non-Demented Swedish Elderly with and without Home Care Services and Vitamin B12 Prescriptions

机译：有或没有家庭护理服务和维生素B12处方的痴呆和非痴呆瑞典老年人中同型半胱氨酸和甲基丙二酸的血药浓度

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background and Aims: Total plasma homocysteine (tHcy) has been suggested as a risk factor of dementia. Our aim was to investigate potential differences in tHcy status in relation to the prescription of vitamin B12 and dementia diagnosis. We examined whether vitamin B12 prescriptions, a family history of dementia, or the need for home care service might be associated with tHcy values. Methods: A cross-sectional monocenter study comprising 926 consecutive subjects attending our Memory Care Unit was conducted. Results: Demented subjects being prescribed vitamin B12 had higher serum vitamin B12 (p = 0.025) but also higher tHcy (p < 0.001) and serum methylmalonate (p = 0.032), and lower serum folate (p < 0.001) than those who did not receive vitamin B12 prescriptions. tHcy levels were significantly higher in non-demented subjects receiving home care service (p = 0.007). This group also had lower serum albumin (dementia: p < 0.001; non-dementia: p = 0.004). There was no difference in renal function (estimated glomerular filtration rate) in demented or non-demented subjects with or without vitamin B12 prescriptions (dementia with/without vitamin B12 prescription: p = 0.561; non-dementia with/without vitamin B12 prescription: p = 0.710). Conclusion: Despite vitamin B12 prescriptions, demented subjects had higher tHcy and methylmalonate values. The elevated metabolite values could not be explained by differences in renal function. Thus, elderly subjects on vitamin B12 prescription appear to have unmet nutritional needs.
机译：背景与目的：总血浆同型半胱氨酸（tHcy）被认为是痴呆的危险因素。我们的目的是调查与维生素B 12 的处方和痴呆症诊断相关的tHcy状态的潜在差异。我们检查了维生素B 12 处方，痴呆症家族史或家庭护理服务的需求是否与tHcy值相关。方法：进行了一项横断面单中心研究，该研究包括926名连续参加我们记忆护理部门的受试者。结果：处方维生素B 12 的痴呆受试者血清维生素B 12 较高（p = 0.025），但tHcy（p <0.001）和血清丙二酸甲酯（p = 0.032）也较高），并比未接受维生素B 12 处方的患者降低血清叶酸（p <0.001）。在接受家庭护理服务的非痴呆患者中，tHcy水平显着更高（p = 0.007）。该组的血清白蛋白也较低（痴呆：p <0.001;非痴呆：p = 0.004）。患有或未患有维生素B 12 处方（患有或未患有维生素B 12 处方的痴呆患者）的肾功能（估计的肾小球滤过率）无差异：p = 0.561;有/无维生素B 12 处方的非痴呆症：p = 0.710）。结论：尽管有维生素B 12 处方，但痴呆的受试者的tHcy和丙二酸甲酯值较高。不能通过肾脏功能的差异来解释代谢物值的升高。因此，服用维生素B 12 处方的老年受试者似乎营养需求未得到满足。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号