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首页> 外文期刊>Dementia and Geriatric Cognitive Disorders Extra >The Combination of Dysexecutive and Amnestic Deficits Strongly Predicts Conversion to Dementia in Young Mild Cognitive Impairment Patients: A Report from the Gothenburg-Oslo MCI Study
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The Combination of Dysexecutive and Amnestic Deficits Strongly Predicts Conversion to Dementia in Young Mild Cognitive Impairment Patients: A Report from the Gothenburg-Oslo MCI Study

机译：执行失忆和遗忘症的结合强烈预测年轻的轻度认知障碍患者向痴呆的转化：来自哥德堡-奥斯陆MCI研究的报告

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Background/Aims: The present study aimed to add to the knowledge of mild cognitive impairment (MCI) by studying the prognosis in a relatively young cohort of patients characterized by neuropsychological criteria. Methods: Patients (mean age: 63 years) with cognitive complaints and MCI (n = 302) were recruited from two university clinics and followed for 2 years. Results: Pure dysexecutive MCI occurred in 11.7% of the neuropsychologically impaired patients, while 59.3 and 29.0% were characterized as having pure amnestic MCI or multidomain MCI. During the study period, the state of 2 (10.5%) of the patients with single-domain dysexecutive MCI converted to dementia, while 28 (29.2%) of the patients with pure amnestic MCI became demented. Of the patients with both executive and amnestic deficits, 28 (59.6%) became demented. Conclusion: The results suggest that dysexecutive symptoms in combination with amnestic symptoms constitute a strong risk factor for dementia in young MCI patients. A significant number of patients in all subgroups showed normal test results at follow-up, indicating that a neuropsychological diagnosis needs to be supported by imaging or biomarker data.
机译：背景/目的：本研究旨在通过研究相对较年轻的以神经心理学标准为特征的患者的预后，增加对轻度认知障碍（MCI）的认识。方法：从两家大学诊所招募患有认知障碍和MCI（n = 302）的患者（平均年龄：63岁），并随访2年。结果：11.7％的神经心理障碍患者发生纯的执行不良MCI，而59.3％和29.0％的患者具有纯记忆消除MCI或多域MCI。在研究期间，单域功能不全MCI患者中有2名（10.5％）的状态转化为痴呆，而纯记忆性MCI患者中有28名（29.2％）的状态变为痴呆。在执行和记忆缺失的患者中，有28位（59.6％）痴呆。结论：研究结果表明，执行不力的症状与遗忘症状共同构成了年轻MCI患者痴呆的重要危险因素。所有亚组中的大量患者在随访时均显示正常的测试结果，表明神经心理学诊断需要影像学或生物标志物数据的支持。

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